from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2852c/mqo

LFCtreatmentdescriptionclass of inhibitor

-1.312

Amikacinug/mL Amikacintranslation

-0.763

Cap5-10ug/mL Capreomycintranslation

-1.290

Rox10-50 ug/mL Roxithromycintranslation

-1.042

SM2-5 ug/mL Streptomycintranslation

-1.749

Tet5-10 ug/mL Tetracyclinetranslation

-0.090

Rif0.2-5ug/mL Rifampicintranscription

0.420

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

2.332

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.857

CPZ10-50 ug/mL Chlorpromazinerespiration

0.000

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.053

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.000

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.107

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

1.489

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.288

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

1.306

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

4.133

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.883

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.426

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

1.339

Nigericin50 uM Nigericinrespiration

0.311

TRC10-150 ug/mL Triclosanrespiration

0.000

TRZ10-25 ug/mL Thioridazinerespiration

1.856

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

1.651

menadione6-10 ug/mL Menadionerespiration

0.348

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.147

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.256

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.000

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.965

NRP_1Non-replicating persistence stage 1dosRassociated

-0.003

Amp0.2mg/mL AmpicillincellWall

-0.120

Cephalexin20-100 ug/mL CephalexincellWall

-0.132

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.520

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.414

EMB10-20 ug/mL EthambutolcellWall

-1.862

Eta12-40 ug/mL EthionamidecellWall

-2.034

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.169

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-1.830

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.320

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.418

BZA0.12 mg/mL BenzamidearomaticAmides

-0.268

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.654

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.648

H2O24 mM hydrogen peroxideDNAdamaging

0.127

Levo10 ug/mL LevofloxacinDNAdamaging

-0.214

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.636

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.401

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.177

UVUV-irradiationDNAdamaging

0.761

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.027

Antimycin12.5-50 ug/mL Antimycin A?

1.359

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.615

PA_110-50 ug/mL Antitubercular compound PA-1?

0.035

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.356

PA8240.2-2 ug/mL PA-824?

0.792

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.452

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.000

Verapamil50 uM Verapamil?

0.000

mercaptoethanol2 mM 2-Mercaptoethanol?

3.934

methoxatin10-20 ug/mL Methoxatin?