from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2844/-

LFCtreatmentdescriptionclass of inhibitor

-0.646

Amikacinug/mL Amikacintranslation

-0.134

Cap5-10ug/mL Capreomycintranslation

0.093

Rox10-50 ug/mL Roxithromycintranslation

0.882

SM2-5 ug/mL Streptomycintranslation

-0.288

Tet5-10 ug/mL Tetracyclinetranslation

-1.193

Rif0.2-5ug/mL Rifampicintranscription

-1.511

Rifp0.1-0.5ug/mL Rifapentinetranscription

-1.571

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.877

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.355

CPZ10-50 ug/mL Chlorpromazinerespiration

0.139

Clofazimine10-13 ug/mL Clofaziminerespiration

0.641

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.912

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-2.181

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.829

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.474

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.570

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.695

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.423

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.222

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.588

KCN5-20 ug/mL Potassium cyaniderespiration

0.422

NaN30.2-2 mM Sodium aziderespiration

1.124

Nigericin50 uM Nigericinrespiration

-1.187

TRC10-150 ug/mL Triclosanrespiration

-1.684

TRZ10-25 ug/mL Thioridazinerespiration

-0.990

Valinomycin0.5-10 uM Valinomycinrespiration

0.555

ZnSO42 mM ZnSO4respiration

-0.223

menadione6-10 ug/mL Menadionerespiration

-0.078

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.692

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.258

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.786

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.397

NRP_1Non-replicating persistence stage 1dosRassociated

0.668

Amp0.2mg/mL AmpicillincellWall

0.428

Cephalexin20-100 ug/mL CephalexincellWall

0.459

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.214

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.041

EMB10-20 ug/mL EthambutolcellWall

-0.264

Eta12-40 ug/mL EthionamidecellWall

-0.169

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.397

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.050

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.725

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.817

BZA0.12 mg/mL BenzamidearomaticAmides

0.796

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.993

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.092

H2O24 mM hydrogen peroxideDNAdamaging

0.063

Levo10 ug/mL LevofloxacinDNAdamaging

0.432

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.751

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.275

Oflox5-10 ug/mL OfloxacinDNAdamaging

1.200

UVUV-irradiationDNAdamaging

-0.389

ARP41-4 ug/mL Antitubercular compound ARP4?

0.418

Antimycin12.5-50 ug/mL Antimycin A?

0.436

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.183

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.198

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.252

PA8240.2-2 ug/mL PA-824?

-0.088

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.482

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.155

Verapamil50 uM Verapamil?

0.599

mercaptoethanol2 mM 2-Mercaptoethanol?

1.013

methoxatin10-20 ug/mL Methoxatin?