from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2839c/infB

LFCtreatmentdescriptionclass of inhibitor

0.983

Amikacinug/mL Amikacintranslation

0.534

Cap5-10ug/mL Capreomycintranslation

0.804

Rox10-50 ug/mL Roxithromycintranslation

2.259

SM2-5 ug/mL Streptomycintranslation

2.588

Tet5-10 ug/mL Tetracyclinetranslation

-1.509

Rif0.2-5ug/mL Rifampicintranscription

-0.075

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.535

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.202

CPZ10-50 ug/mL Chlorpromazinerespiration

0.000

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.243

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.000

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.601

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-1.093

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.668

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.291

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-1.620

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.060

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-1.845

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.359

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

-0.919

Nigericin50 uM Nigericinrespiration

-0.778

TRC10-150 ug/mL Triclosanrespiration

0.941

TRZ10-25 ug/mL Thioridazinerespiration

1.643

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.234

menadione6-10 ug/mL Menadionerespiration

-0.099

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.564

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.256

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.599

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-1.061

NRP_1Non-replicating persistence stage 1dosRassociated

0.065

Amp0.2mg/mL AmpicillincellWall

0.030

Cephalexin20-100 ug/mL CephalexincellWall

-0.022

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.099

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.159

EMB10-20 ug/mL EthambutolcellWall

0.038

Eta12-40 ug/mL EthionamidecellWall

0.563

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.188

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.614

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.591

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.083

BZA0.12 mg/mL BenzamidearomaticAmides

0.351

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.986

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.712

H2O24 mM hydrogen peroxideDNAdamaging

-0.165

Levo10 ug/mL LevofloxacinDNAdamaging

0.266

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.333

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.087

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.615

UVUV-irradiationDNAdamaging

0.000

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.216

Antimycin12.5-50 ug/mL Antimycin A?

-1.470

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.185

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.453

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.017

PA8240.2-2 ug/mL PA-824?

0.577

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.154

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.000

Verapamil50 uM Verapamil?

-1.461

mercaptoethanol2 mM 2-Mercaptoethanol?

0.256

methoxatin10-20 ug/mL Methoxatin?