from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2830c/vapB22

LFCtreatmentdescriptionclass of inhibitor

-1.010

Amikacinug/mL Amikacintranslation

-0.867

Cap5-10ug/mL Capreomycintranslation

-1.205

Rox10-50 ug/mL Roxithromycintranslation

-0.505

SM2-5 ug/mL Streptomycintranslation

-0.255

Tet5-10 ug/mL Tetracyclinetranslation

-0.290

Rif0.2-5ug/mL Rifampicintranscription

-0.974

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.138

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

2.033

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.112

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.175

Clofazimine10-13 ug/mL Clofaziminerespiration

-1.045

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

1.395

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

2.162

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.801

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-1.274

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.918

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.786

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.518

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.370

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.639

KCN5-20 ug/mL Potassium cyaniderespiration

0.244

NaN30.2-2 mM Sodium aziderespiration

-1.025

Nigericin50 uM Nigericinrespiration

0.680

TRC10-150 ug/mL Triclosanrespiration

1.123

TRZ10-25 ug/mL Thioridazinerespiration

1.127

Valinomycin0.5-10 uM Valinomycinrespiration

-1.656

ZnSO42 mM ZnSO4respiration

-0.075

menadione6-10 ug/mL Menadionerespiration

-0.225

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.694

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.153

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.475

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.967

NRP_1Non-replicating persistence stage 1dosRassociated

0.342

Amp0.2mg/mL AmpicillincellWall

-0.259

Cephalexin20-100 ug/mL CephalexincellWall

-0.867

Cerulenin0.32-5 ug/mL CerulenincellWall

0.134

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.055

EMB10-20 ug/mL EthambutolcellWall

-0.655

Eta12-40 ug/mL EthionamidecellWall

-0.471

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.347

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-1.217

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.645

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.411

BZA0.12 mg/mL BenzamidearomaticAmides

0.975

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.509

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.390

H2O24 mM hydrogen peroxideDNAdamaging

-1.383

Levo10 ug/mL LevofloxacinDNAdamaging

0.180

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.726

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.856

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.797

UVUV-irradiationDNAdamaging

0.229

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.283

Antimycin12.5-50 ug/mL Antimycin A?

-1.260

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.232

PA_110-50 ug/mL Antitubercular compound PA-1?

0.323

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.047

PA8240.2-2 ug/mL PA-824?

0.621

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.183

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.940

Verapamil50 uM Verapamil?

-0.946

mercaptoethanol2 mM 2-Mercaptoethanol?

-1.893

methoxatin10-20 ug/mL Methoxatin?