from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2806/-

LFCtreatmentdescriptionclass of inhibitor

1.076

Amikacinug/mL Amikacintranslation

0.000

Cap5-10ug/mL Capreomycintranslation

0.000

Rox10-50 ug/mL Roxithromycintranslation

0.846

SM2-5 ug/mL Streptomycintranslation

0.000

Tet5-10 ug/mL Tetracyclinetranslation

-0.706

Rif0.2-5ug/mL Rifampicintranscription

0.000

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.327

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.110

CPZ10-50 ug/mL Chlorpromazinerespiration

0.000

Clofazimine10-13 ug/mL Clofaziminerespiration

0.000

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.000

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.000

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-1.772

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.000

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-1.006

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.249

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.818

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.000

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

0.828

Nigericin50 uM Nigericinrespiration

0.923

TRC10-150 ug/mL Triclosanrespiration

0.000

TRZ10-25 ug/mL Thioridazinerespiration

-1.065

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.650

menadione6-10 ug/mL Menadionerespiration

-0.089

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

1.605

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.992

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.473

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.668

NRP_1Non-replicating persistence stage 1dosRassociated

0.469

Amp0.2mg/mL AmpicillincellWall

-0.461

Cephalexin20-100 ug/mL CephalexincellWall

1.960

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.889

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.999

EMB10-20 ug/mL EthambutolcellWall

-1.118

Eta12-40 ug/mL EthionamidecellWall

-0.989

INH0.2-0.4 ug/mL IsoniazidcellWall

0.000

TLM0.1-0.2 mg/mL ThiolactomycincellWall

1.470

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.000

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.323

BZA0.12 mg/mL BenzamidearomaticAmides

-0.159

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.107

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.857

H2O24 mM hydrogen peroxideDNAdamaging

0.000

Levo10 ug/mL LevofloxacinDNAdamaging

0.329

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

1.423

Novobiocin10 ug/mL NovobiocinDNAdamaging

1.721

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.311

UVUV-irradiationDNAdamaging

1.344

ARP41-4 ug/mL Antitubercular compound ARP4?

0.000

Antimycin12.5-50 ug/mL Antimycin A?

-0.291

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.062

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.045

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.845

PA8240.2-2 ug/mL PA-824?

0.569

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

3.416

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.925

Verapamil50 uM Verapamil?

-0.570

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.336

methoxatin10-20 ug/mL Methoxatin?