from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2799/-

LFCtreatmentdescriptionclass of inhibitor

0.207

Amikacinug/mL Amikacintranslation

0.482

Cap5-10ug/mL Capreomycintranslation

0.705

Rox10-50 ug/mL Roxithromycintranslation

-0.034

SM2-5 ug/mL Streptomycintranslation

0.000

Tet5-10 ug/mL Tetracyclinetranslation

1.414

Rif0.2-5ug/mL Rifampicintranscription

0.570

Rifp0.1-0.5ug/mL Rifapentinetranscription

1.738

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.007

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.143

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.141

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.171

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.069

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.837

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.190

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.419

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.615

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.084

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.394

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.602

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.211

KCN5-20 ug/mL Potassium cyaniderespiration

0.114

NaN30.2-2 mM Sodium aziderespiration

0.462

Nigericin50 uM Nigericinrespiration

-0.418

TRC10-150 ug/mL Triclosanrespiration

-0.956

TRZ10-25 ug/mL Thioridazinerespiration

-0.778

Valinomycin0.5-10 uM Valinomycinrespiration

0.444

ZnSO42 mM ZnSO4respiration

-0.767

menadione6-10 ug/mL Menadionerespiration

0.353

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.668

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.625

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.176

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.006

NRP_1Non-replicating persistence stage 1dosRassociated

0.500

Amp0.2mg/mL AmpicillincellWall

-0.075

Cephalexin20-100 ug/mL CephalexincellWall

0.149

Cerulenin0.32-5 ug/mL CerulenincellWall

0.551

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.406

EMB10-20 ug/mL EthambutolcellWall

1.302

Eta12-40 ug/mL EthionamidecellWall

0.401

INH0.2-0.4 ug/mL IsoniazidcellWall

0.066

TLM0.1-0.2 mg/mL ThiolactomycincellWall

1.044

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.796

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.889

BZA0.12 mg/mL BenzamidearomaticAmides

-0.008

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.104

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.844

H2O24 mM hydrogen peroxideDNAdamaging

0.781

Levo10 ug/mL LevofloxacinDNAdamaging

0.039

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.286

Novobiocin10 ug/mL NovobiocinDNAdamaging

1.313

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.369

UVUV-irradiationDNAdamaging

-0.943

ARP41-4 ug/mL Antitubercular compound ARP4?

0.493

Antimycin12.5-50 ug/mL Antimycin A?

-0.125

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.243

PA_110-50 ug/mL Antitubercular compound PA-1?

0.830

PA_2110-50 ug/mL Antitubercular compound PA-21?

1.716

PA8240.2-2 ug/mL PA-824?

-0.450

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.246

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.004

Verapamil50 uM Verapamil?

-0.033

mercaptoethanol2 mM 2-Mercaptoethanol?

0.111

methoxatin10-20 ug/mL Methoxatin?