from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2798c/-

LFCtreatmentdescriptionclass of inhibitor

-0.712

Amikacinug/mL Amikacintranslation

-0.106

Cap5-10ug/mL Capreomycintranslation

0.119

Rox10-50 ug/mL Roxithromycintranslation

-0.357

SM2-5 ug/mL Streptomycintranslation

-0.168

Tet5-10 ug/mL Tetracyclinetranslation

-1.612

Rif0.2-5ug/mL Rifampicintranscription

-0.450

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.000

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.099

CPZ10-50 ug/mL Chlorpromazinerespiration

0.000

Clofazimine10-13 ug/mL Clofaziminerespiration

0.118

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.000

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.000

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

1.833

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.233

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

1.569

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.000

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

2.528

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.000

KCN5-20 ug/mL Potassium cyaniderespiration

0.908

NaN30.2-2 mM Sodium aziderespiration

2.013

Nigericin50 uM Nigericinrespiration

-1.008

TRC10-150 ug/mL Triclosanrespiration

0.000

TRZ10-25 ug/mL Thioridazinerespiration

1.906

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

2.214

menadione6-10 ug/mL Menadionerespiration

-0.027

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.134

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.212

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.084

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

3.521

NRP_1Non-replicating persistence stage 1dosRassociated

-0.273

Amp0.2mg/mL AmpicillincellWall

-0.328

Cephalexin20-100 ug/mL CephalexincellWall

0.260

Cerulenin0.32-5 ug/mL CerulenincellWall

-1.232

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.359

EMB10-20 ug/mL EthambutolcellWall

-0.218

Eta12-40 ug/mL EthionamidecellWall

0.215

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.219

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.000

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.000

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.224

BZA0.12 mg/mL BenzamidearomaticAmides

0.215

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.810

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.424

H2O24 mM hydrogen peroxideDNAdamaging

0.389

Levo10 ug/mL LevofloxacinDNAdamaging

0.005

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

6.521

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.392

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.350

UVUV-irradiationDNAdamaging

0.000

ARP41-4 ug/mL Antitubercular compound ARP4?

0.615

Antimycin12.5-50 ug/mL Antimycin A?

2.552

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.040

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.117

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.484

PA8240.2-2 ug/mL PA-824?

-0.265

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.178

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

2.328

Verapamil50 uM Verapamil?

3.293

mercaptoethanol2 mM 2-Mercaptoethanol?

0.000

methoxatin10-20 ug/mL Methoxatin?