from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2797c/-

LFCtreatmentdescriptionclass of inhibitor

0.000

Amikacinug/mL Amikacintranslation

1.419

Cap5-10ug/mL Capreomycintranslation

1.475

Rox10-50 ug/mL Roxithromycintranslation

0.000

SM2-5 ug/mL Streptomycintranslation

0.000

Tet5-10 ug/mL Tetracyclinetranslation

-0.340

Rif0.2-5ug/mL Rifampicintranscription

0.000

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.756

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

1.579

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.101

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.235

Clofazimine10-13 ug/mL Clofaziminerespiration

0.373

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

1.439

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.492

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.248

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.159

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.804

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.370

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.289

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.595

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.397

KCN5-20 ug/mL Potassium cyaniderespiration

-0.307

NaN30.2-2 mM Sodium aziderespiration

-0.398

Nigericin50 uM Nigericinrespiration

1.296

TRC10-150 ug/mL Triclosanrespiration

0.734

TRZ10-25 ug/mL Thioridazinerespiration

-0.789

Valinomycin0.5-10 uM Valinomycinrespiration

-1.247

ZnSO42 mM ZnSO4respiration

-0.742

menadione6-10 ug/mL Menadionerespiration

0.906

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

1.102

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.525

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.802

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.258

NRP_1Non-replicating persistence stage 1dosRassociated

0.000

Amp0.2mg/mL AmpicillincellWall

0.225

Cephalexin20-100 ug/mL CephalexincellWall

1.528

Cerulenin0.32-5 ug/mL CerulenincellWall

-2.079

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.438

EMB10-20 ug/mL EthambutolcellWall

0.000

Eta12-40 ug/mL EthionamidecellWall

0.000

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.971

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.490

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.120

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.335

BZA0.12 mg/mL BenzamidearomaticAmides

-0.557

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.309

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.031

H2O24 mM hydrogen peroxideDNAdamaging

0.000

Levo10 ug/mL LevofloxacinDNAdamaging

-0.526

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.530

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.000

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.732

UVUV-irradiationDNAdamaging

1.437

ARP41-4 ug/mL Antitubercular compound ARP4?

0.550

Antimycin12.5-50 ug/mL Antimycin A?

-0.446

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

1.111

PA_110-50 ug/mL Antitubercular compound PA-1?

1.303

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.317

PA8240.2-2 ug/mL PA-824?

0.010

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

1.180

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.199

Verapamil50 uM Verapamil?

0.194

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.555

methoxatin10-20 ug/mL Methoxatin?