from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2795c/-

LFCtreatmentdescriptionclass of inhibitor

-1.318

Amikacinug/mL Amikacintranslation

-0.781

Cap5-10ug/mL Capreomycintranslation

-1.925

Rox10-50 ug/mL Roxithromycintranslation

0.878

SM2-5 ug/mL Streptomycintranslation

-0.541

Tet5-10 ug/mL Tetracyclinetranslation

-0.135

Rif0.2-5ug/mL Rifampicintranscription

0.169

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.451

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-2.872

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.510

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.567

Clofazimine10-13 ug/mL Clofaziminerespiration

0.121

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.343

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.700

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.149

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.952

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.180

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.611

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.598

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.382

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.311

KCN5-20 ug/mL Potassium cyaniderespiration

-0.182

NaN30.2-2 mM Sodium aziderespiration

-0.021

Nigericin50 uM Nigericinrespiration

-0.372

TRC10-150 ug/mL Triclosanrespiration

-1.159

TRZ10-25 ug/mL Thioridazinerespiration

-0.664

Valinomycin0.5-10 uM Valinomycinrespiration

1.019

ZnSO42 mM ZnSO4respiration

0.274

menadione6-10 ug/mL Menadionerespiration

0.027

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.432

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.097

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.770

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.465

NRP_1Non-replicating persistence stage 1dosRassociated

-0.046

Amp0.2mg/mL AmpicillincellWall

-0.219

Cephalexin20-100 ug/mL CephalexincellWall

0.601

Cerulenin0.32-5 ug/mL CerulenincellWall

0.612

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.041

EMB10-20 ug/mL EthambutolcellWall

0.358

Eta12-40 ug/mL EthionamidecellWall

1.440

INH0.2-0.4 ug/mL IsoniazidcellWall

0.660

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.360

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.547

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.077

BZA0.12 mg/mL BenzamidearomaticAmides

0.026

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.126

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.229

H2O24 mM hydrogen peroxideDNAdamaging

1.106

Levo10 ug/mL LevofloxacinDNAdamaging

0.239

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

1.533

Novobiocin10 ug/mL NovobiocinDNAdamaging

1.116

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.370

UVUV-irradiationDNAdamaging

-2.079

ARP41-4 ug/mL Antitubercular compound ARP4?

0.597

Antimycin12.5-50 ug/mL Antimycin A?

0.374

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.486

PA_110-50 ug/mL Antitubercular compound PA-1?

0.587

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.633

PA8240.2-2 ug/mL PA-824?

0.015

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.168

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.335

Verapamil50 uM Verapamil?

0.523

mercaptoethanol2 mM 2-Mercaptoethanol?

0.543

methoxatin10-20 ug/mL Methoxatin?