from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2794c/pptT

LFCtreatmentdescriptionclass of inhibitor

-3.408

Amikacinug/mL Amikacintranslation

-0.904

Cap5-10ug/mL Capreomycintranslation

-0.823

Rox10-50 ug/mL Roxithromycintranslation

-1.283

SM2-5 ug/mL Streptomycintranslation

-1.235

Tet5-10 ug/mL Tetracyclinetranslation

-0.792

Rif0.2-5ug/mL Rifampicintranscription

-0.683

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.375

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.493

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.218

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.543

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.757

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.020

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.607

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.115

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.737

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.451

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.318

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.409

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.063

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.350

KCN5-20 ug/mL Potassium cyaniderespiration

-0.119

NaN30.2-2 mM Sodium aziderespiration

-0.705

Nigericin50 uM Nigericinrespiration

0.106

TRC10-150 ug/mL Triclosanrespiration

-1.611

TRZ10-25 ug/mL Thioridazinerespiration

-1.130

Valinomycin0.5-10 uM Valinomycinrespiration

-1.142

ZnSO42 mM ZnSO4respiration

0.437

menadione6-10 ug/mL Menadionerespiration

-0.107

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.318

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.314

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.544

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.156

NRP_1Non-replicating persistence stage 1dosRassociated

0.389

Amp0.2mg/mL AmpicillincellWall

-0.305

Cephalexin20-100 ug/mL CephalexincellWall

-0.506

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.167

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.167

EMB10-20 ug/mL EthambutolcellWall

0.153

Eta12-40 ug/mL EthionamidecellWall

0.491

INH0.2-0.4 ug/mL IsoniazidcellWall

0.044

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-1.590

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.377

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.944

BZA0.12 mg/mL BenzamidearomaticAmides

1.097

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

1.028

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.764

H2O24 mM hydrogen peroxideDNAdamaging

-0.718

Levo10 ug/mL LevofloxacinDNAdamaging

0.785

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.513

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.276

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.766

UVUV-irradiationDNAdamaging

-0.678

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.466

Antimycin12.5-50 ug/mL Antimycin A?

-0.758

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.190

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.042

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.068

PA8240.2-2 ug/mL PA-824?

-0.175

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.186

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.854

Verapamil50 uM Verapamil?

-0.405

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.867

methoxatin10-20 ug/mL Methoxatin?