from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2785c/rpsO

LFCtreatmentdescriptionclass of inhibitor

1.274

Amikacinug/mL Amikacintranslation

1.660

Cap5-10ug/mL Capreomycintranslation

3.526

Rox10-50 ug/mL Roxithromycintranslation

1.245

SM2-5 ug/mL Streptomycintranslation

3.004

Tet5-10 ug/mL Tetracyclinetranslation

-0.269

Rif0.2-5ug/mL Rifampicintranscription

0.019

Rifp0.1-0.5ug/mL Rifapentinetranscription

1.458

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.919

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.724

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.405

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.371

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.187

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.954

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.784

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.563

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.329

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.888

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.002

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-1.046

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.176

KCN5-20 ug/mL Potassium cyaniderespiration

-0.979

NaN30.2-2 mM Sodium aziderespiration

0.990

Nigericin50 uM Nigericinrespiration

-0.190

TRC10-150 ug/mL Triclosanrespiration

-1.688

TRZ10-25 ug/mL Thioridazinerespiration

0.563

Valinomycin0.5-10 uM Valinomycinrespiration

0.406

ZnSO42 mM ZnSO4respiration

-0.344

menadione6-10 ug/mL Menadionerespiration

-0.073

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.085

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.079

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.227

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

1.209

NRP_1Non-replicating persistence stage 1dosRassociated

0.617

Amp0.2mg/mL AmpicillincellWall

-0.021

Cephalexin20-100 ug/mL CephalexincellWall

0.691

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.490

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.180

EMB10-20 ug/mL EthambutolcellWall

1.251

Eta12-40 ug/mL EthionamidecellWall

1.823

INH0.2-0.4 ug/mL IsoniazidcellWall

0.549

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.645

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.128

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.505

BZA0.12 mg/mL BenzamidearomaticAmides

-0.122

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.065

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.681

H2O24 mM hydrogen peroxideDNAdamaging

-0.083

Levo10 ug/mL LevofloxacinDNAdamaging

0.173

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.094

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.260

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.033

UVUV-irradiationDNAdamaging

0.026

ARP41-4 ug/mL Antitubercular compound ARP4?

0.191

Antimycin12.5-50 ug/mL Antimycin A?

-0.169

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.279

PA_110-50 ug/mL Antitubercular compound PA-1?

0.297

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.526

PA8240.2-2 ug/mL PA-824?

-0.073

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.559

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.064

Verapamil50 uM Verapamil?

-0.484

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.051

methoxatin10-20 ug/mL Methoxatin?