from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2767c/-

LFCtreatmentdescriptionclass of inhibitor

0.736

Amikacinug/mL Amikacintranslation

0.489

Cap5-10ug/mL Capreomycintranslation

0.761

Rox10-50 ug/mL Roxithromycintranslation

0.782

SM2-5 ug/mL Streptomycintranslation

0.672

Tet5-10 ug/mL Tetracyclinetranslation

0.390

Rif0.2-5ug/mL Rifampicintranscription

-0.161

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.286

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-2.198

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.517

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.575

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.218

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.516

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.062

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.847

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.182

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.671

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.122

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.096

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-1.884

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.754

KCN5-20 ug/mL Potassium cyaniderespiration

-0.925

NaN30.2-2 mM Sodium aziderespiration

-0.068

Nigericin50 uM Nigericinrespiration

-0.037

TRC10-150 ug/mL Triclosanrespiration

-1.317

TRZ10-25 ug/mL Thioridazinerespiration

1.524

Valinomycin0.5-10 uM Valinomycinrespiration

0.824

ZnSO42 mM ZnSO4respiration

-1.672

menadione6-10 ug/mL Menadionerespiration

-0.105

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.434

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.520

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.285

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

1.294

NRP_1Non-replicating persistence stage 1dosRassociated

0.040

Amp0.2mg/mL AmpicillincellWall

-0.196

Cephalexin20-100 ug/mL CephalexincellWall

0.233

Cerulenin0.32-5 ug/mL CerulenincellWall

0.211

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.146

EMB10-20 ug/mL EthambutolcellWall

0.624

Eta12-40 ug/mL EthionamidecellWall

-0.142

INH0.2-0.4 ug/mL IsoniazidcellWall

0.998

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.297

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.157

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.423

BZA0.12 mg/mL BenzamidearomaticAmides

-0.107

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.622

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.248

H2O24 mM hydrogen peroxideDNAdamaging

-0.138

Levo10 ug/mL LevofloxacinDNAdamaging

-0.045

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.584

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.102

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.401

UVUV-irradiationDNAdamaging

0.094

ARP41-4 ug/mL Antitubercular compound ARP4?

0.164

Antimycin12.5-50 ug/mL Antimycin A?

-0.029

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.385

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.259

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.113

PA8240.2-2 ug/mL PA-824?

-0.314

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.079

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.506

Verapamil50 uM Verapamil?

-0.362

mercaptoethanol2 mM 2-Mercaptoethanol?

0.109

methoxatin10-20 ug/mL Methoxatin?