from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2738c/-

LFCtreatmentdescriptionclass of inhibitor

-0.656

Amikacinug/mL Amikacintranslation

0.067

Cap5-10ug/mL Capreomycintranslation

-0.582

Rox10-50 ug/mL Roxithromycintranslation

0.253

SM2-5 ug/mL Streptomycintranslation

0.123

Tet5-10 ug/mL Tetracyclinetranslation

-0.156

Rif0.2-5ug/mL Rifampicintranscription

-0.519

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.099

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.530

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.148

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.685

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.112

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.630

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.856

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.332

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.379

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.336

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.457

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.624

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.292

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.270

KCN5-20 ug/mL Potassium cyaniderespiration

-0.872

NaN30.2-2 mM Sodium aziderespiration

-0.453

Nigericin50 uM Nigericinrespiration

-0.072

TRC10-150 ug/mL Triclosanrespiration

-0.015

TRZ10-25 ug/mL Thioridazinerespiration

-1.267

Valinomycin0.5-10 uM Valinomycinrespiration

-0.579

ZnSO42 mM ZnSO4respiration

0.144

menadione6-10 ug/mL Menadionerespiration

0.691

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.068

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.294

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.521

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

1.715

NRP_1Non-replicating persistence stage 1dosRassociated

0.254

Amp0.2mg/mL AmpicillincellWall

-0.139

Cephalexin20-100 ug/mL CephalexincellWall

0.228

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.640

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.076

EMB10-20 ug/mL EthambutolcellWall

0.561

Eta12-40 ug/mL EthionamidecellWall

0.538

INH0.2-0.4 ug/mL IsoniazidcellWall

0.833

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-1.136

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.047

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.383

BZA0.12 mg/mL BenzamidearomaticAmides

-0.211

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.417

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.423

H2O24 mM hydrogen peroxideDNAdamaging

0.696

Levo10 ug/mL LevofloxacinDNAdamaging

0.494

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.109

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.610

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.161

UVUV-irradiationDNAdamaging

1.358

ARP41-4 ug/mL Antitubercular compound ARP4?

0.507

Antimycin12.5-50 ug/mL Antimycin A?

0.570

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.932

PA_110-50 ug/mL Antitubercular compound PA-1?

0.787

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.869

PA8240.2-2 ug/mL PA-824?

0.058

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.702

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.225

Verapamil50 uM Verapamil?

0.597

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.473

methoxatin10-20 ug/mL Methoxatin?