from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2736c/recX

LFCtreatmentdescriptionclass of inhibitor

-0.234

Amikacinug/mL Amikacintranslation

-1.157

Cap5-10ug/mL Capreomycintranslation

-1.053

Rox10-50 ug/mL Roxithromycintranslation

-0.010

SM2-5 ug/mL Streptomycintranslation

0.116

Tet5-10 ug/mL Tetracyclinetranslation

-0.505

Rif0.2-5ug/mL Rifampicintranscription

-0.410

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.839

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.604

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.816

CPZ10-50 ug/mL Chlorpromazinerespiration

0.193

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.367

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.963

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.963

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.380

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.609

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.235

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-1.866

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.804

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.128

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.714

KCN5-20 ug/mL Potassium cyaniderespiration

-0.474

NaN30.2-2 mM Sodium aziderespiration

-0.433

Nigericin50 uM Nigericinrespiration

-0.761

TRC10-150 ug/mL Triclosanrespiration

-0.986

TRZ10-25 ug/mL Thioridazinerespiration

-0.093

Valinomycin0.5-10 uM Valinomycinrespiration

-0.391

ZnSO42 mM ZnSO4respiration

0.350

menadione6-10 ug/mL Menadionerespiration

-0.285

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.145

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.092

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.195

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-1.102

NRP_1Non-replicating persistence stage 1dosRassociated

0.177

Amp0.2mg/mL AmpicillincellWall

0.146

Cephalexin20-100 ug/mL CephalexincellWall

-0.006

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.162

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.106

EMB10-20 ug/mL EthambutolcellWall

0.283

Eta12-40 ug/mL EthionamidecellWall

0.378

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.027

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.216

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.354

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.314

BZA0.12 mg/mL BenzamidearomaticAmides

-0.101

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.078

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

1.653

H2O24 mM hydrogen peroxideDNAdamaging

0.632

Levo10 ug/mL LevofloxacinDNAdamaging

1.459

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.513

Novobiocin10 ug/mL NovobiocinDNAdamaging

1.089

Oflox5-10 ug/mL OfloxacinDNAdamaging

3.142

UVUV-irradiationDNAdamaging

-0.897

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.298

Antimycin12.5-50 ug/mL Antimycin A?

0.377

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.196

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.194

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.354

PA8240.2-2 ug/mL PA-824?

0.458

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.239

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.007

Verapamil50 uM Verapamil?

0.202

mercaptoethanol2 mM 2-Mercaptoethanol?

0.233

methoxatin10-20 ug/mL Methoxatin?