from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2732c/-

LFCtreatmentdescriptionclass of inhibitor

0.195

Amikacinug/mL Amikacintranslation

-0.997

Cap5-10ug/mL Capreomycintranslation

-1.771

Rox10-50 ug/mL Roxithromycintranslation

-0.016

SM2-5 ug/mL Streptomycintranslation

0.247

Tet5-10 ug/mL Tetracyclinetranslation

1.422

Rif0.2-5ug/mL Rifampicintranscription

0.753

Rifp0.1-0.5ug/mL Rifapentinetranscription

-2.063

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.995

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.090

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.114

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.357

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.945

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.316

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.460

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.746

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.435

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.118

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.189

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.112

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.614

KCN5-20 ug/mL Potassium cyaniderespiration

0.158

NaN30.2-2 mM Sodium aziderespiration

-1.060

Nigericin50 uM Nigericinrespiration

0.224

TRC10-150 ug/mL Triclosanrespiration

-0.763

TRZ10-25 ug/mL Thioridazinerespiration

-2.671

Valinomycin0.5-10 uM Valinomycinrespiration

-0.616

ZnSO42 mM ZnSO4respiration

-0.047

menadione6-10 ug/mL Menadionerespiration

0.311

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.075

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.096

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.908

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.553

NRP_1Non-replicating persistence stage 1dosRassociated

0.288

Amp0.2mg/mL AmpicillincellWall

-0.002

Cephalexin20-100 ug/mL CephalexincellWall

-0.093

Cerulenin0.32-5 ug/mL CerulenincellWall

0.823

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.804

EMB10-20 ug/mL EthambutolcellWall

0.226

Eta12-40 ug/mL EthionamidecellWall

0.068

INH0.2-0.4 ug/mL IsoniazidcellWall

0.682

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-1.310

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.277

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.177

BZA0.12 mg/mL BenzamidearomaticAmides

0.242

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.039

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.818

H2O24 mM hydrogen peroxideDNAdamaging

0.039

Levo10 ug/mL LevofloxacinDNAdamaging

0.671

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.945

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.771

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.227

UVUV-irradiationDNAdamaging

-0.204

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.101

Antimycin12.5-50 ug/mL Antimycin A?

-1.178

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.556

PA_110-50 ug/mL Antitubercular compound PA-1?

0.426

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.073

PA8240.2-2 ug/mL PA-824?

0.390

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.292

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.911

Verapamil50 uM Verapamil?

-0.502

mercaptoethanol2 mM 2-Mercaptoethanol?

-1.374

methoxatin10-20 ug/mL Methoxatin?