from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2717c/-

LFCtreatmentdescriptionclass of inhibitor

2.095

Amikacinug/mL Amikacintranslation

2.726

Cap5-10ug/mL Capreomycintranslation

1.038

Rox10-50 ug/mL Roxithromycintranslation

0.892

SM2-5 ug/mL Streptomycintranslation

2.251

Tet5-10 ug/mL Tetracyclinetranslation

-0.014

Rif0.2-5ug/mL Rifampicintranscription

-0.026

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.000

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.726

CPZ10-50 ug/mL Chlorpromazinerespiration

0.000

Clofazimine10-13 ug/mL Clofaziminerespiration

0.330

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.000

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.000

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.401

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.312

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.000

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.033

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.000

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.000

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

0.864

Nigericin50 uM Nigericinrespiration

-0.795

TRC10-150 ug/mL Triclosanrespiration

0.000

TRZ10-25 ug/mL Thioridazinerespiration

0.933

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

0.000

menadione6-10 ug/mL Menadionerespiration

-0.699

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.090

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.462

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.000

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.000

NRP_1Non-replicating persistence stage 1dosRassociated

-0.419

Amp0.2mg/mL AmpicillincellWall

-0.639

Cephalexin20-100 ug/mL CephalexincellWall

-0.189

Cerulenin0.32-5 ug/mL CerulenincellWall

0.006

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.431

EMB10-20 ug/mL EthambutolcellWall

-0.430

Eta12-40 ug/mL EthionamidecellWall

-0.519

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.309

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.000

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.000

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.194

BZA0.12 mg/mL BenzamidearomaticAmides

-0.447

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.504

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.222

H2O24 mM hydrogen peroxideDNAdamaging

0.850

Levo10 ug/mL LevofloxacinDNAdamaging

0.045

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.000

Novobiocin10 ug/mL NovobiocinDNAdamaging

2.191

Oflox5-10 ug/mL OfloxacinDNAdamaging

1.729

UVUV-irradiationDNAdamaging

0.000

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.102

Antimycin12.5-50 ug/mL Antimycin A?

0.916

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.524

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.616

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.299

PA8240.2-2 ug/mL PA-824?

-0.696

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.320

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.115

Verapamil50 uM Verapamil?

1.615

mercaptoethanol2 mM 2-Mercaptoethanol?

1.761

methoxatin10-20 ug/mL Methoxatin?