from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2713/sthA

LFCtreatmentdescriptionclass of inhibitor

3.150

Amikacinug/mL Amikacintranslation

2.198

Cap5-10ug/mL Capreomycintranslation

2.470

Rox10-50 ug/mL Roxithromycintranslation

0.811

SM2-5 ug/mL Streptomycintranslation

3.244

Tet5-10 ug/mL Tetracyclinetranslation

-0.291

Rif0.2-5ug/mL Rifampicintranscription

1.249

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.175

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.968

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.885

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.167

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.313

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.816

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.646

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.672

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.516

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.068

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.498

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.535

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.042

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.140

KCN5-20 ug/mL Potassium cyaniderespiration

-0.044

NaN30.2-2 mM Sodium aziderespiration

0.278

Nigericin50 uM Nigericinrespiration

-0.554

TRC10-150 ug/mL Triclosanrespiration

-0.988

TRZ10-25 ug/mL Thioridazinerespiration

1.711

Valinomycin0.5-10 uM Valinomycinrespiration

-1.258

ZnSO42 mM ZnSO4respiration

-0.666

menadione6-10 ug/mL Menadionerespiration

0.364

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.399

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.501

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.495

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.651

NRP_1Non-replicating persistence stage 1dosRassociated

0.151

Amp0.2mg/mL AmpicillincellWall

-0.123

Cephalexin20-100 ug/mL CephalexincellWall

0.271

Cerulenin0.32-5 ug/mL CerulenincellWall

0.521

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.192

EMB10-20 ug/mL EthambutolcellWall

0.442

Eta12-40 ug/mL EthionamidecellWall

0.628

INH0.2-0.4 ug/mL IsoniazidcellWall

0.086

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.323

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.155

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.313

BZA0.12 mg/mL BenzamidearomaticAmides

-0.385

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.226

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.384

H2O24 mM hydrogen peroxideDNAdamaging

-0.664

Levo10 ug/mL LevofloxacinDNAdamaging

-0.271

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.076

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.773

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.034

UVUV-irradiationDNAdamaging

-0.897

ARP41-4 ug/mL Antitubercular compound ARP4?

0.011

Antimycin12.5-50 ug/mL Antimycin A?

0.042

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.708

PA_110-50 ug/mL Antitubercular compound PA-1?

0.423

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.033

PA8240.2-2 ug/mL PA-824?

-0.933

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.016

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.093

Verapamil50 uM Verapamil?

0.008

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.067

methoxatin10-20 ug/mL Methoxatin?