from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2701c/suhB

LFCtreatmentdescriptionclass of inhibitor

0.053

Amikacinug/mL Amikacintranslation

0.346

Cap5-10ug/mL Capreomycintranslation

-0.322

Rox10-50 ug/mL Roxithromycintranslation

-0.043

SM2-5 ug/mL Streptomycintranslation

-1.004

Tet5-10 ug/mL Tetracyclinetranslation

0.295

Rif0.2-5ug/mL Rifampicintranscription

-0.286

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.891

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

2.006

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.353

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.700

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.606

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

1.471

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.079

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

1.821

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.169

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.198

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.239

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.000

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.448

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

1.285

KCN5-20 ug/mL Potassium cyaniderespiration

2.561

NaN30.2-2 mM Sodium aziderespiration

-0.073

Nigericin50 uM Nigericinrespiration

0.283

TRC10-150 ug/mL Triclosanrespiration

0.411

TRZ10-25 ug/mL Thioridazinerespiration

-0.357

Valinomycin0.5-10 uM Valinomycinrespiration

5.032

ZnSO42 mM ZnSO4respiration

-0.558

menadione6-10 ug/mL Menadionerespiration

-0.133

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.138

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.102

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.633

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.450

NRP_1Non-replicating persistence stage 1dosRassociated

-0.358

Amp0.2mg/mL AmpicillincellWall

-0.043

Cephalexin20-100 ug/mL CephalexincellWall

-0.118

Cerulenin0.32-5 ug/mL CerulenincellWall

0.078

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.026

EMB10-20 ug/mL EthambutolcellWall

-0.089

Eta12-40 ug/mL EthionamidecellWall

0.133

INH0.2-0.4 ug/mL IsoniazidcellWall

0.031

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.523

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.050

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.339

BZA0.12 mg/mL BenzamidearomaticAmides

-0.440

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.164

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.002

H2O24 mM hydrogen peroxideDNAdamaging

0.021

Levo10 ug/mL LevofloxacinDNAdamaging

-0.492

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.044

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.238

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.343

UVUV-irradiationDNAdamaging

-1.525

ARP41-4 ug/mL Antitubercular compound ARP4?

0.305

Antimycin12.5-50 ug/mL Antimycin A?

-0.302

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.531

PA_110-50 ug/mL Antitubercular compound PA-1?

0.442

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.890

PA8240.2-2 ug/mL PA-824?

-0.065

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.135

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.166

Verapamil50 uM Verapamil?

0.174

mercaptoethanol2 mM 2-Mercaptoethanol?

0.202

methoxatin10-20 ug/mL Methoxatin?