from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2696c/-

LFCtreatmentdescriptionclass of inhibitor

-0.696

Amikacinug/mL Amikacintranslation

-1.751

Cap5-10ug/mL Capreomycintranslation

-1.257

Rox10-50 ug/mL Roxithromycintranslation

0.296

SM2-5 ug/mL Streptomycintranslation

-0.295

Tet5-10 ug/mL Tetracyclinetranslation

-0.030

Rif0.2-5ug/mL Rifampicintranscription

-1.390

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.726

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.391

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.106

CPZ10-50 ug/mL Chlorpromazinerespiration

0.427

Clofazimine10-13 ug/mL Clofaziminerespiration

0.179

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.702

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.670

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.692

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.314

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.370

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.215

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.412

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.530

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.439

KCN5-20 ug/mL Potassium cyaniderespiration

-0.036

NaN30.2-2 mM Sodium aziderespiration

-0.224

Nigericin50 uM Nigericinrespiration

-0.570

TRC10-150 ug/mL Triclosanrespiration

-0.127

TRZ10-25 ug/mL Thioridazinerespiration

-1.151

Valinomycin0.5-10 uM Valinomycinrespiration

0.706

ZnSO42 mM ZnSO4respiration

-0.043

menadione6-10 ug/mL Menadionerespiration

0.392

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.124

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.597

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.309

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

2.895

NRP_1Non-replicating persistence stage 1dosRassociated

0.028

Amp0.2mg/mL AmpicillincellWall

0.236

Cephalexin20-100 ug/mL CephalexincellWall

-0.174

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.059

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.226

EMB10-20 ug/mL EthambutolcellWall

0.425

Eta12-40 ug/mL EthionamidecellWall

0.601

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.206

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.439

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.293

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.530

BZA0.12 mg/mL BenzamidearomaticAmides

-0.335

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.488

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.735

H2O24 mM hydrogen peroxideDNAdamaging

-0.709

Levo10 ug/mL LevofloxacinDNAdamaging

0.314

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.040

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.112

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.490

UVUV-irradiationDNAdamaging

2.037

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.011

Antimycin12.5-50 ug/mL Antimycin A?

0.206

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.410

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.460

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.611

PA8240.2-2 ug/mL PA-824?

0.480

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.829

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.755

Verapamil50 uM Verapamil?

-0.227

mercaptoethanol2 mM 2-Mercaptoethanol?

0.198

methoxatin10-20 ug/mL Methoxatin?