from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2694c/-

LFCtreatmentdescriptionclass of inhibitor

0.204

Amikacinug/mL Amikacintranslation

-0.669

Cap5-10ug/mL Capreomycintranslation

0.381

Rox10-50 ug/mL Roxithromycintranslation

-0.239

SM2-5 ug/mL Streptomycintranslation

-0.070

Tet5-10 ug/mL Tetracyclinetranslation

-0.707

Rif0.2-5ug/mL Rifampicintranscription

-1.145

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.868

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.426

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

1.225

CPZ10-50 ug/mL Chlorpromazinerespiration

1.169

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.245

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

2.925

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.632

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.263

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.162

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.400

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

1.718

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.028

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.889

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

1.791

KCN5-20 ug/mL Potassium cyaniderespiration

-0.275

NaN30.2-2 mM Sodium aziderespiration

0.557

Nigericin50 uM Nigericinrespiration

-0.018

TRC10-150 ug/mL Triclosanrespiration

2.954

TRZ10-25 ug/mL Thioridazinerespiration

0.777

Valinomycin0.5-10 uM Valinomycinrespiration

-0.210

ZnSO42 mM ZnSO4respiration

0.241

menadione6-10 ug/mL Menadionerespiration

0.050

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.794

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.615

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.840

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.596

NRP_1Non-replicating persistence stage 1dosRassociated

-0.829

Amp0.2mg/mL AmpicillincellWall

-0.662

Cephalexin20-100 ug/mL CephalexincellWall

-0.658

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.683

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.520

EMB10-20 ug/mL EthambutolcellWall

-0.516

Eta12-40 ug/mL EthionamidecellWall

-0.330

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.841

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.548

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.057

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.386

BZA0.12 mg/mL BenzamidearomaticAmides

0.354

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.988

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.003

H2O24 mM hydrogen peroxideDNAdamaging

-1.013

Levo10 ug/mL LevofloxacinDNAdamaging

-0.462

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.651

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.565

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.493

UVUV-irradiationDNAdamaging

1.002

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.991

Antimycin12.5-50 ug/mL Antimycin A?

-0.695

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-1.150

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.837

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.789

PA8240.2-2 ug/mL PA-824?

-0.022

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.470

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.086

Verapamil50 uM Verapamil?

-0.958

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.857

methoxatin10-20 ug/mL Methoxatin?