from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2692/ceoC

LFCtreatmentdescriptionclass of inhibitor

0.008

Amikacinug/mL Amikacintranslation

-0.638

Cap5-10ug/mL Capreomycintranslation

-0.563

Rox10-50 ug/mL Roxithromycintranslation

0.176

SM2-5 ug/mL Streptomycintranslation

-0.433

Tet5-10 ug/mL Tetracyclinetranslation

0.648

Rif0.2-5ug/mL Rifampicintranscription

-0.492

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.121

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.474

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.821

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.754

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.248

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.851

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-1.560

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.211

Econazole10-24 ug/mL Econazole (azole drug)respiration

-3.919

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.995

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.203

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.007

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.000

KCN5-20 ug/mL Potassium cyaniderespiration

-0.230

NaN30.2-2 mM Sodium aziderespiration

-0.794

Nigericin50 uM Nigericinrespiration

0.061

TRC10-150 ug/mL Triclosanrespiration

-0.709

TRZ10-25 ug/mL Thioridazinerespiration

-1.340

Valinomycin0.5-10 uM Valinomycinrespiration

0.102

ZnSO42 mM ZnSO4respiration

-1.402

menadione6-10 ug/mL Menadionerespiration

-0.559

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.375

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.415

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-1.575

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-1.396

NRP_1Non-replicating persistence stage 1dosRassociated

0.207

Amp0.2mg/mL AmpicillincellWall

0.082

Cephalexin20-100 ug/mL CephalexincellWall

-0.270

Cerulenin0.32-5 ug/mL CerulenincellWall

0.218

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.294

EMB10-20 ug/mL EthambutolcellWall

-0.143

Eta12-40 ug/mL EthionamidecellWall

-0.091

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.021

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.266

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.204

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.175

BZA0.12 mg/mL BenzamidearomaticAmides

0.983

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.847

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.262

H2O24 mM hydrogen peroxideDNAdamaging

-0.098

Levo10 ug/mL LevofloxacinDNAdamaging

0.327

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-2.452

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.858

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.257

UVUV-irradiationDNAdamaging

0.493

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.091

Antimycin12.5-50 ug/mL Antimycin A?

-1.087

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.525

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.472

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.691

PA8240.2-2 ug/mL PA-824?

-0.672

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.581

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.000

Verapamil50 uM Verapamil?

-1.345

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.506

methoxatin10-20 ug/mL Methoxatin?