from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2689c/-

LFCtreatmentdescriptionclass of inhibitor

-0.221

Amikacinug/mL Amikacintranslation

-0.208

Cap5-10ug/mL Capreomycintranslation

0.877

Rox10-50 ug/mL Roxithromycintranslation

-0.329

SM2-5 ug/mL Streptomycintranslation

-1.059

Tet5-10 ug/mL Tetracyclinetranslation

0.976

Rif0.2-5ug/mL Rifampicintranscription

-0.134

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.181

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.700

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.430

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.166

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.733

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.377

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.922

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-1.591

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.443

Econazole10-24 ug/mL Econazole (azole drug)respiration

-1.002

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.603

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.086

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.942

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.222

KCN5-20 ug/mL Potassium cyaniderespiration

0.576

NaN30.2-2 mM Sodium aziderespiration

0.318

Nigericin50 uM Nigericinrespiration

-0.381

TRC10-150 ug/mL Triclosanrespiration

-0.818

TRZ10-25 ug/mL Thioridazinerespiration

-0.402

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.494

menadione6-10 ug/mL Menadionerespiration

-0.425

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-1.597

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.482

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.054

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.287

NRP_1Non-replicating persistence stage 1dosRassociated

0.015

Amp0.2mg/mL AmpicillincellWall

0.529

Cephalexin20-100 ug/mL CephalexincellWall

-0.036

Cerulenin0.32-5 ug/mL CerulenincellWall

0.136

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.336

EMB10-20 ug/mL EthambutolcellWall

1.046

Eta12-40 ug/mL EthionamidecellWall

0.154

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.264

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.782

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.073

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.092

BZA0.12 mg/mL BenzamidearomaticAmides

0.284

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.923

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.745

H2O24 mM hydrogen peroxideDNAdamaging

-0.054

Levo10 ug/mL LevofloxacinDNAdamaging

0.235

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.929

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.271

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.328

UVUV-irradiationDNAdamaging

-0.160

ARP41-4 ug/mL Antitubercular compound ARP4?

0.797

Antimycin12.5-50 ug/mL Antimycin A?

0.391

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.339

PA_110-50 ug/mL Antitubercular compound PA-1?

1.039

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.620

PA8240.2-2 ug/mL PA-824?

-0.318

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.231

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.610

Verapamil50 uM Verapamil?

-0.059

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.867

methoxatin10-20 ug/mL Methoxatin?