from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2633c/-

LFCtreatmentdescriptionclass of inhibitor

1.516

Amikacinug/mL Amikacintranslation

1.450

Cap5-10ug/mL Capreomycintranslation

1.283

Rox10-50 ug/mL Roxithromycintranslation

-0.256

SM2-5 ug/mL Streptomycintranslation

1.488

Tet5-10 ug/mL Tetracyclinetranslation

-0.030

Rif0.2-5ug/mL Rifampicintranscription

-0.007

Rifp0.1-0.5ug/mL Rifapentinetranscription

2.131

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.478

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.043

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.280

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.090

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.969

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.011

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.901

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.128

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.937

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.207

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.648

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-1.060

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.410

KCN5-20 ug/mL Potassium cyaniderespiration

-0.363

NaN30.2-2 mM Sodium aziderespiration

0.693

Nigericin50 uM Nigericinrespiration

-0.355

TRC10-150 ug/mL Triclosanrespiration

0.274

TRZ10-25 ug/mL Thioridazinerespiration

-1.488

Valinomycin0.5-10 uM Valinomycinrespiration

0.291

ZnSO42 mM ZnSO4respiration

-1.100

menadione6-10 ug/mL Menadionerespiration

0.935

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.296

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

1.075

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.636

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

1.234

NRP_1Non-replicating persistence stage 1dosRassociated

0.400

Amp0.2mg/mL AmpicillincellWall

0.214

Cephalexin20-100 ug/mL CephalexincellWall

-0.831

Cerulenin0.32-5 ug/mL CerulenincellWall

1.147

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.448

EMB10-20 ug/mL EthambutolcellWall

0.370

Eta12-40 ug/mL EthionamidecellWall

-0.033

INH0.2-0.4 ug/mL IsoniazidcellWall

0.132

TLM0.1-0.2 mg/mL ThiolactomycincellWall

1.769

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.080

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.047

BZA0.12 mg/mL BenzamidearomaticAmides

-1.078

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-1.060

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.625

H2O24 mM hydrogen peroxideDNAdamaging

0.764

Levo10 ug/mL LevofloxacinDNAdamaging

0.116

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.072

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.325

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.269

UVUV-irradiationDNAdamaging

-1.423

ARP41-4 ug/mL Antitubercular compound ARP4?

0.487

Antimycin12.5-50 ug/mL Antimycin A?

0.430

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.112

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.069

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.199

PA8240.2-2 ug/mL PA-824?

-1.330

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.705

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.728

Verapamil50 uM Verapamil?

0.733

mercaptoethanol2 mM 2-Mercaptoethanol?

0.328

methoxatin10-20 ug/mL Methoxatin?