from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2632c/-

LFCtreatmentdescriptionclass of inhibitor

2.285

Amikacinug/mL Amikacintranslation

2.767

Cap5-10ug/mL Capreomycintranslation

2.187

Rox10-50 ug/mL Roxithromycintranslation

-0.029

SM2-5 ug/mL Streptomycintranslation

1.172

Tet5-10 ug/mL Tetracyclinetranslation

-0.843

Rif0.2-5ug/mL Rifampicintranscription

-0.676

Rifp0.1-0.5ug/mL Rifapentinetranscription

4.460

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.319

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.137

CPZ10-50 ug/mL Chlorpromazinerespiration

1.004

Clofazimine10-13 ug/mL Clofaziminerespiration

0.440

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.545

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.433

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.119

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.581

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.804

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.020

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.905

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.219

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.949

KCN5-20 ug/mL Potassium cyaniderespiration

0.302

NaN30.2-2 mM Sodium aziderespiration

0.981

Nigericin50 uM Nigericinrespiration

-0.659

TRC10-150 ug/mL Triclosanrespiration

1.101

TRZ10-25 ug/mL Thioridazinerespiration

-1.103

Valinomycin0.5-10 uM Valinomycinrespiration

0.564

ZnSO42 mM ZnSO4respiration

-0.025

menadione6-10 ug/mL Menadionerespiration

0.815

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.020

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.294

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.032

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.052

NRP_1Non-replicating persistence stage 1dosRassociated

-0.146

Amp0.2mg/mL AmpicillincellWall

-0.161

Cephalexin20-100 ug/mL CephalexincellWall

-0.517

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.229

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.399

EMB10-20 ug/mL EthambutolcellWall

-0.337

Eta12-40 ug/mL EthionamidecellWall

-0.494

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.566

TLM0.1-0.2 mg/mL ThiolactomycincellWall

1.587

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.451

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.644

BZA0.12 mg/mL BenzamidearomaticAmides

-0.675

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.719

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.286

H2O24 mM hydrogen peroxideDNAdamaging

-0.248

Levo10 ug/mL LevofloxacinDNAdamaging

-0.220

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.630

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.800

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.064

UVUV-irradiationDNAdamaging

-0.550

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.328

Antimycin12.5-50 ug/mL Antimycin A?

0.207

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.556

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.394

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.629

PA8240.2-2 ug/mL PA-824?

-1.141

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.746

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.944

Verapamil50 uM Verapamil?

0.392

mercaptoethanol2 mM 2-Mercaptoethanol?

0.110

methoxatin10-20 ug/mL Methoxatin?