from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2629/-

LFCtreatmentdescriptionclass of inhibitor

-0.710

Amikacinug/mL Amikacintranslation

-0.901

Cap5-10ug/mL Capreomycintranslation

-0.476

Rox10-50 ug/mL Roxithromycintranslation

-0.949

SM2-5 ug/mL Streptomycintranslation

-0.249

Tet5-10 ug/mL Tetracyclinetranslation

-0.384

Rif0.2-5ug/mL Rifampicintranscription

-0.877

Rifp0.1-0.5ug/mL Rifapentinetranscription

1.499

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.577

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.200

CPZ10-50 ug/mL Chlorpromazinerespiration

0.448

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.302

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

2.599

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.087

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.556

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.412

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.236

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.117

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.389

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.015

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

3.921

KCN5-20 ug/mL Potassium cyaniderespiration

-0.152

NaN30.2-2 mM Sodium aziderespiration

0.006

Nigericin50 uM Nigericinrespiration

0.041

TRC10-150 ug/mL Triclosanrespiration

1.292

TRZ10-25 ug/mL Thioridazinerespiration

0.566

Valinomycin0.5-10 uM Valinomycinrespiration

-0.747

ZnSO42 mM ZnSO4respiration

-0.112

menadione6-10 ug/mL Menadionerespiration

0.232

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.371

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.329

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.098

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.625

NRP_1Non-replicating persistence stage 1dosRassociated

-0.748

Amp0.2mg/mL AmpicillincellWall

-0.077

Cephalexin20-100 ug/mL CephalexincellWall

-0.517

Cerulenin0.32-5 ug/mL CerulenincellWall

-1.076

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.537

EMB10-20 ug/mL EthambutolcellWall

-0.605

Eta12-40 ug/mL EthionamidecellWall

-0.479

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.513

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.164

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.629

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.172

BZA0.12 mg/mL BenzamidearomaticAmides

-0.148

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.023

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.458

H2O24 mM hydrogen peroxideDNAdamaging

-0.886

Levo10 ug/mL LevofloxacinDNAdamaging

-0.653

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.941

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.868

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.976

UVUV-irradiationDNAdamaging

1.444

ARP41-4 ug/mL Antitubercular compound ARP4?

0.011

Antimycin12.5-50 ug/mL Antimycin A?

-0.429

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.764

PA_110-50 ug/mL Antitubercular compound PA-1?

0.516

PA_2110-50 ug/mL Antitubercular compound PA-21?

1.697

PA8240.2-2 ug/mL PA-824?

2.040

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

1.115

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.201

Verapamil50 uM Verapamil?

-0.200

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.663

methoxatin10-20 ug/mL Methoxatin?