from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2626c/hrp1

LFCtreatmentdescriptionclass of inhibitor

-0.136

Amikacinug/mL Amikacintranslation

0.236

Cap5-10ug/mL Capreomycintranslation

0.205

Rox10-50 ug/mL Roxithromycintranslation

-0.241

SM2-5 ug/mL Streptomycintranslation

0.520

Tet5-10 ug/mL Tetracyclinetranslation

-0.018

Rif0.2-5ug/mL Rifampicintranscription

-0.030

Rifp0.1-0.5ug/mL Rifapentinetranscription

4.012

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.392

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.594

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.830

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.055

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.074

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.145

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.324

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.086

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.881

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

1.882

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.910

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.466

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.865

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

-0.598

Nigericin50 uM Nigericinrespiration

-0.135

TRC10-150 ug/mL Triclosanrespiration

0.119

TRZ10-25 ug/mL Thioridazinerespiration

0.311

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.209

menadione6-10 ug/mL Menadionerespiration

-0.306

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.458

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.241

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

2.595

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

3.938

NRP_1Non-replicating persistence stage 1dosRassociated

-0.479

Amp0.2mg/mL AmpicillincellWall

-0.217

Cephalexin20-100 ug/mL CephalexincellWall

-0.167

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.355

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.289

EMB10-20 ug/mL EthambutolcellWall

-0.626

Eta12-40 ug/mL EthionamidecellWall

-0.765

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.604

TLM0.1-0.2 mg/mL ThiolactomycincellWall

2.188

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.963

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.613

BZA0.12 mg/mL BenzamidearomaticAmides

-0.530

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.687

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.072

H2O24 mM hydrogen peroxideDNAdamaging

-0.165

Levo10 ug/mL LevofloxacinDNAdamaging

-0.177

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.120

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.375

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.145

UVUV-irradiationDNAdamaging

-0.163

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.122

Antimycin12.5-50 ug/mL Antimycin A?

-0.044

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.419

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.389

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.012

PA8240.2-2 ug/mL PA-824?

2.167

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.572

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.635

Verapamil50 uM Verapamil?

0.365

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.579

methoxatin10-20 ug/mL Methoxatin?