from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2624c/-

LFCtreatmentdescriptionclass of inhibitor

-0.258

Amikacinug/mL Amikacintranslation

0.159

Cap5-10ug/mL Capreomycintranslation

0.126

Rox10-50 ug/mL Roxithromycintranslation

-0.492

SM2-5 ug/mL Streptomycintranslation

-0.602

Tet5-10 ug/mL Tetracyclinetranslation

-0.041

Rif0.2-5ug/mL Rifampicintranscription

-0.572

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.197

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.002

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.289

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.206

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.217

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.738

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.160

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.102

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.271

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.303

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.287

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.321

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.248

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.431

KCN5-20 ug/mL Potassium cyaniderespiration

-0.566

NaN30.2-2 mM Sodium aziderespiration

-0.109

Nigericin50 uM Nigericinrespiration

0.005

TRC10-150 ug/mL Triclosanrespiration

0.130

TRZ10-25 ug/mL Thioridazinerespiration

0.328

Valinomycin0.5-10 uM Valinomycinrespiration

-0.862

ZnSO42 mM ZnSO4respiration

-0.617

menadione6-10 ug/mL Menadionerespiration

-0.236

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.363

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.499

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.742

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

4.783

NRP_1Non-replicating persistence stage 1dosRassociated

-0.493

Amp0.2mg/mL AmpicillincellWall

-0.282

Cephalexin20-100 ug/mL CephalexincellWall

-0.577

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.275

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.514

EMB10-20 ug/mL EthambutolcellWall

-1.120

Eta12-40 ug/mL EthionamidecellWall

-1.158

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.603

TLM0.1-0.2 mg/mL ThiolactomycincellWall

1.219

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.609

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.250

BZA0.12 mg/mL BenzamidearomaticAmides

0.221

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.135

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.348

H2O24 mM hydrogen peroxideDNAdamaging

-0.197

Levo10 ug/mL LevofloxacinDNAdamaging

-0.110

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.067

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.630

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.021

UVUV-irradiationDNAdamaging

0.596

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.327

Antimycin12.5-50 ug/mL Antimycin A?

-0.264

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.587

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.257

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.017

PA8240.2-2 ug/mL PA-824?

3.209

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.247

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.019

Verapamil50 uM Verapamil?

-0.037

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.084

methoxatin10-20 ug/mL Methoxatin?