from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2623/TB31.7

LFCtreatmentdescriptionclass of inhibitor

0.170

Amikacinug/mL Amikacintranslation

-0.049

Cap5-10ug/mL Capreomycintranslation

0.418

Rox10-50 ug/mL Roxithromycintranslation

0.840

SM2-5 ug/mL Streptomycintranslation

0.000

Tet5-10 ug/mL Tetracyclinetranslation

-0.419

Rif0.2-5ug/mL Rifampicintranscription

0.089

Rifp0.1-0.5ug/mL Rifapentinetranscription

2.354

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.279

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.148

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.726

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.141

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.249

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.208

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.046

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.134

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.237

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.717

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.608

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.340

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

-0.803

Nigericin50 uM Nigericinrespiration

-0.140

TRC10-150 ug/mL Triclosanrespiration

-0.070

TRZ10-25 ug/mL Thioridazinerespiration

-0.185

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.913

menadione6-10 ug/mL Menadionerespiration

0.102

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.026

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.196

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

1.200

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

4.177

NRP_1Non-replicating persistence stage 1dosRassociated

-0.377

Amp0.2mg/mL AmpicillincellWall

-0.260

Cephalexin20-100 ug/mL CephalexincellWall

0.199

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.356

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.170

EMB10-20 ug/mL EthambutolcellWall

0.238

Eta12-40 ug/mL EthionamidecellWall

-0.394

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.013

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.755

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.005

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.589

BZA0.12 mg/mL BenzamidearomaticAmides

-0.662

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.518

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.070

H2O24 mM hydrogen peroxideDNAdamaging

-0.219

Levo10 ug/mL LevofloxacinDNAdamaging

-0.161

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.613

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.138

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.103

UVUV-irradiationDNAdamaging

0.184

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.223

Antimycin12.5-50 ug/mL Antimycin A?

-0.289

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.095

PA_110-50 ug/mL Antitubercular compound PA-1?

0.162

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.474

PA8240.2-2 ug/mL PA-824?

4.571

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.097

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.831

Verapamil50 uM Verapamil?

-0.564

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.687

methoxatin10-20 ug/mL Methoxatin?