from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2620c/-

LFCtreatmentdescriptionclass of inhibitor

-1.178

Amikacinug/mL Amikacintranslation

-0.105

Cap5-10ug/mL Capreomycintranslation

-0.589

Rox10-50 ug/mL Roxithromycintranslation

-1.065

SM2-5 ug/mL Streptomycintranslation

-0.860

Tet5-10 ug/mL Tetracyclinetranslation

-0.231

Rif0.2-5ug/mL Rifampicintranscription

-0.193

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.528

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.886

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.028

CPZ10-50 ug/mL Chlorpromazinerespiration

0.640

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.582

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

1.664

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.046

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.732

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.623

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.676

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

1.245

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

7.435

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.485

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

1.628

KCN5-20 ug/mL Potassium cyaniderespiration

-0.501

NaN30.2-2 mM Sodium aziderespiration

-0.544

Nigericin50 uM Nigericinrespiration

0.488

TRC10-150 ug/mL Triclosanrespiration

0.991

TRZ10-25 ug/mL Thioridazinerespiration

0.863

Valinomycin0.5-10 uM Valinomycinrespiration

-1.739

ZnSO42 mM ZnSO4respiration

0.305

menadione6-10 ug/mL Menadionerespiration

-0.397

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.524

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.284

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.999

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.036

NRP_1Non-replicating persistence stage 1dosRassociated

-0.445

Amp0.2mg/mL AmpicillincellWall

-0.136

Cephalexin20-100 ug/mL CephalexincellWall

-0.316

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.425

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.476

EMB10-20 ug/mL EthambutolcellWall

-1.568

Eta12-40 ug/mL EthionamidecellWall

-1.229

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.193

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.236

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.872

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.004

BZA0.12 mg/mL BenzamidearomaticAmides

-0.217

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.530

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.068

H2O24 mM hydrogen peroxideDNAdamaging

-0.377

Levo10 ug/mL LevofloxacinDNAdamaging

0.173

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.222

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.407

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.306

UVUV-irradiationDNAdamaging

0.875

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.198

Antimycin12.5-50 ug/mL Antimycin A?

-0.325

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.248

PA_110-50 ug/mL Antitubercular compound PA-1?

0.085

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.217

PA8240.2-2 ug/mL PA-824?

0.225

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.140

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.516

Verapamil50 uM Verapamil?

-0.203

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.874

methoxatin10-20 ug/mL Methoxatin?