from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2571c/-

LFCtreatmentdescriptionclass of inhibitor

0.006

Amikacinug/mL Amikacintranslation

-0.643

Cap5-10ug/mL Capreomycintranslation

-0.890

Rox10-50 ug/mL Roxithromycintranslation

1.012

SM2-5 ug/mL Streptomycintranslation

-0.968

Tet5-10 ug/mL Tetracyclinetranslation

-0.027

Rif0.2-5ug/mL Rifampicintranscription

0.307

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.513

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.459

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.426

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.395

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.285

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.039

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.889

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-1.192

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.295

Econazole10-24 ug/mL Econazole (azole drug)respiration

1.028

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.461

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.107

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.397

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.595

KCN5-20 ug/mL Potassium cyaniderespiration

-0.746

NaN30.2-2 mM Sodium aziderespiration

0.186

Nigericin50 uM Nigericinrespiration

0.349

TRC10-150 ug/mL Triclosanrespiration

-1.208

TRZ10-25 ug/mL Thioridazinerespiration

-1.513

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

0.093

menadione6-10 ug/mL Menadionerespiration

-0.269

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.013

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.108

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.312

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.461

NRP_1Non-replicating persistence stage 1dosRassociated

0.059

Amp0.2mg/mL AmpicillincellWall

-0.048

Cephalexin20-100 ug/mL CephalexincellWall

0.135

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.373

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.259

EMB10-20 ug/mL EthambutolcellWall

0.567

Eta12-40 ug/mL EthionamidecellWall

0.699

INH0.2-0.4 ug/mL IsoniazidcellWall

0.520

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.280

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.088

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.597

BZA0.12 mg/mL BenzamidearomaticAmides

0.773

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

2.110

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.179

H2O24 mM hydrogen peroxideDNAdamaging

0.061

Levo10 ug/mL LevofloxacinDNAdamaging

-0.211

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-2.028

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.020

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.227

UVUV-irradiationDNAdamaging

0.357

ARP41-4 ug/mL Antitubercular compound ARP4?

0.204

Antimycin12.5-50 ug/mL Antimycin A?

0.102

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.219

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.035

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.752

PA8240.2-2 ug/mL PA-824?

-0.711

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.075

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.105

Verapamil50 uM Verapamil?

-0.082

mercaptoethanol2 mM 2-Mercaptoethanol?

0.246

methoxatin10-20 ug/mL Methoxatin?