from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2547/vapB19

LFCtreatmentdescriptionclass of inhibitor

0.497

Amikacinug/mL Amikacintranslation

0.102

Cap5-10ug/mL Capreomycintranslation

0.062

Rox10-50 ug/mL Roxithromycintranslation

0.422

SM2-5 ug/mL Streptomycintranslation

1.572

Tet5-10 ug/mL Tetracyclinetranslation

1.137

Rif0.2-5ug/mL Rifampicintranscription

-0.424

Rifp0.1-0.5ug/mL Rifapentinetranscription

-1.561

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.030

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.125

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.694

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.477

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.325

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.430

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.315

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.233

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.436

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.283

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.038

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.444

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.164

KCN5-20 ug/mL Potassium cyaniderespiration

-0.843

NaN30.2-2 mM Sodium aziderespiration

-2.042

Nigericin50 uM Nigericinrespiration

0.356

TRC10-150 ug/mL Triclosanrespiration

-0.115

TRZ10-25 ug/mL Thioridazinerespiration

1.228

Valinomycin0.5-10 uM Valinomycinrespiration

0.365

ZnSO42 mM ZnSO4respiration

0.035

menadione6-10 ug/mL Menadionerespiration

-0.324

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.282

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.393

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.994

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.205

NRP_1Non-replicating persistence stage 1dosRassociated

0.249

Amp0.2mg/mL AmpicillincellWall

0.341

Cephalexin20-100 ug/mL CephalexincellWall

0.077

Cerulenin0.32-5 ug/mL CerulenincellWall

1.750

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.985

EMB10-20 ug/mL EthambutolcellWall

0.202

Eta12-40 ug/mL EthionamidecellWall

0.267

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.346

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.170

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.335

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.506

BZA0.12 mg/mL BenzamidearomaticAmides

-0.097

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.291

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.480

H2O24 mM hydrogen peroxideDNAdamaging

0.521

Levo10 ug/mL LevofloxacinDNAdamaging

-0.310

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.868

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.958

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.076

UVUV-irradiationDNAdamaging

-0.927

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.625

Antimycin12.5-50 ug/mL Antimycin A?

-0.015

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.685

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.325

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.519

PA8240.2-2 ug/mL PA-824?

-0.814

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.291

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.044

Verapamil50 uM Verapamil?

0.507

mercaptoethanol2 mM 2-Mercaptoethanol?

0.377

methoxatin10-20 ug/mL Methoxatin?