from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2534c/efp

LFCtreatmentdescriptionclass of inhibitor

1.242

Amikacinug/mL Amikacintranslation

2.653

Cap5-10ug/mL Capreomycintranslation

3.473

Rox10-50 ug/mL Roxithromycintranslation

-0.038

SM2-5 ug/mL Streptomycintranslation

2.783

Tet5-10 ug/mL Tetracyclinetranslation

-1.216

Rif0.2-5ug/mL Rifampicintranscription

-1.288

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.567

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.551

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.320

CPZ10-50 ug/mL Chlorpromazinerespiration

0.291

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.109

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.172

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.568

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.623

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.093

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.319

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.323

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.477

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.414

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.059

KCN5-20 ug/mL Potassium cyaniderespiration

-0.520

NaN30.2-2 mM Sodium aziderespiration

0.074

Nigericin50 uM Nigericinrespiration

-1.931

TRC10-150 ug/mL Triclosanrespiration

-0.761

TRZ10-25 ug/mL Thioridazinerespiration

2.030

Valinomycin0.5-10 uM Valinomycinrespiration

-0.020

ZnSO42 mM ZnSO4respiration

0.048

menadione6-10 ug/mL Menadionerespiration

0.653

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.062

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.047

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.222

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.685

NRP_1Non-replicating persistence stage 1dosRassociated

0.252

Amp0.2mg/mL AmpicillincellWall

0.205

Cephalexin20-100 ug/mL CephalexincellWall

0.222

Cerulenin0.32-5 ug/mL CerulenincellWall

0.347

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.346

EMB10-20 ug/mL EthambutolcellWall

0.340

Eta12-40 ug/mL EthionamidecellWall

0.114

INH0.2-0.4 ug/mL IsoniazidcellWall

0.481

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.206

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.123

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.111

BZA0.12 mg/mL BenzamidearomaticAmides

-0.328

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.048

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.862

H2O24 mM hydrogen peroxideDNAdamaging

0.226

Levo10 ug/mL LevofloxacinDNAdamaging

-0.002

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.257

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.469

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.049

UVUV-irradiationDNAdamaging

-0.290

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.039

Antimycin12.5-50 ug/mL Antimycin A?

0.260

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.161

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.035

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.082

PA8240.2-2 ug/mL PA-824?

-0.124

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.069

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.837

Verapamil50 uM Verapamil?

0.135

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.304

methoxatin10-20 ug/mL Methoxatin?