from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2510c/-

LFCtreatmentdescriptionclass of inhibitor

0.205

Amikacinug/mL Amikacintranslation

-0.051

Cap5-10ug/mL Capreomycintranslation

0.043

Rox10-50 ug/mL Roxithromycintranslation

0.098

SM2-5 ug/mL Streptomycintranslation

0.811

Tet5-10 ug/mL Tetracyclinetranslation

1.084

Rif0.2-5ug/mL Rifampicintranscription

0.077

Rifp0.1-0.5ug/mL Rifapentinetranscription

1.086

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.304

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.250

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.657

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.480

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.222

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.992

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.418

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.476

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.057

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.097

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-2.282

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.457

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-3.204

KCN5-20 ug/mL Potassium cyaniderespiration

-0.370

NaN30.2-2 mM Sodium aziderespiration

-0.149

Nigericin50 uM Nigericinrespiration

0.332

TRC10-150 ug/mL Triclosanrespiration

-0.866

TRZ10-25 ug/mL Thioridazinerespiration

-1.930

Valinomycin0.5-10 uM Valinomycinrespiration

-1.100

ZnSO42 mM ZnSO4respiration

-0.169

menadione6-10 ug/mL Menadionerespiration

0.052

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.069

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.202

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.701

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.731

NRP_1Non-replicating persistence stage 1dosRassociated

0.497

Amp0.2mg/mL AmpicillincellWall

-0.354

Cephalexin20-100 ug/mL CephalexincellWall

-0.390

Cerulenin0.32-5 ug/mL CerulenincellWall

0.611

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.427

EMB10-20 ug/mL EthambutolcellWall

-0.223

Eta12-40 ug/mL EthionamidecellWall

-0.392

INH0.2-0.4 ug/mL IsoniazidcellWall

0.572

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.644

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.425

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.814

BZA0.12 mg/mL BenzamidearomaticAmides

0.644

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.127

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

1.173

H2O24 mM hydrogen peroxideDNAdamaging

0.039

Levo10 ug/mL LevofloxacinDNAdamaging

0.610

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.687

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.578

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.740

UVUV-irradiationDNAdamaging

0.962

ARP41-4 ug/mL Antitubercular compound ARP4?

0.888

Antimycin12.5-50 ug/mL Antimycin A?

-0.269

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.138

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.162

PA_2110-50 ug/mL Antitubercular compound PA-21?

-2.588

PA8240.2-2 ug/mL PA-824?

-0.743

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.008

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.049

Verapamil50 uM Verapamil?

-0.487

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.859

methoxatin10-20 ug/mL Methoxatin?