from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2429/ahpD

LFCtreatmentdescriptionclass of inhibitor

-0.384

Amikacinug/mL Amikacintranslation

-0.576

Cap5-10ug/mL Capreomycintranslation

-0.221

Rox10-50 ug/mL Roxithromycintranslation

1.223

SM2-5 ug/mL Streptomycintranslation

-0.495

Tet5-10 ug/mL Tetracyclinetranslation

-0.801

Rif0.2-5ug/mL Rifampicintranscription

0.277

Rifp0.1-0.5ug/mL Rifapentinetranscription

-3.081

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.800

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.754

CPZ10-50 ug/mL Chlorpromazinerespiration

1.081

Clofazimine10-13 ug/mL Clofaziminerespiration

0.651

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.986

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-2.356

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.513

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.856

Econazole10-24 ug/mL Econazole (azole drug)respiration

1.011

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-1.066

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.999

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.075

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.668

KCN5-20 ug/mL Potassium cyaniderespiration

1.274

NaN30.2-2 mM Sodium aziderespiration

1.954

Nigericin50 uM Nigericinrespiration

-0.972

TRC10-150 ug/mL Triclosanrespiration

-1.505

TRZ10-25 ug/mL Thioridazinerespiration

-0.599

Valinomycin0.5-10 uM Valinomycinrespiration

0.630

ZnSO42 mM ZnSO4respiration

-0.192

menadione6-10 ug/mL Menadionerespiration

1.232

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.369

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

1.434

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.153

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

1.071

NRP_1Non-replicating persistence stage 1dosRassociated

0.241

Amp0.2mg/mL AmpicillincellWall

0.105

Cephalexin20-100 ug/mL CephalexincellWall

1.167

Cerulenin0.32-5 ug/mL CerulenincellWall

0.248

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.525

EMB10-20 ug/mL EthambutolcellWall

1.227

Eta12-40 ug/mL EthionamidecellWall

0.736

INH0.2-0.4 ug/mL IsoniazidcellWall

0.585

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.657

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.580

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.237

BZA0.12 mg/mL BenzamidearomaticAmides

-0.958

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.920

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.476

H2O24 mM hydrogen peroxideDNAdamaging

-0.521

Levo10 ug/mL LevofloxacinDNAdamaging

0.649

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.250

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.003

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.507

UVUV-irradiationDNAdamaging

-0.920

ARP41-4 ug/mL Antitubercular compound ARP4?

0.261

Antimycin12.5-50 ug/mL Antimycin A?

-0.315

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

1.262

PA_110-50 ug/mL Antitubercular compound PA-1?

1.177

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.542

PA8240.2-2 ug/mL PA-824?

0.687

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.259

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.790

Verapamil50 uM Verapamil?

0.470

mercaptoethanol2 mM 2-Mercaptoethanol?

0.452

methoxatin10-20 ug/mL Methoxatin?