from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2412/rpsT

LFCtreatmentdescriptionclass of inhibitor

0.905

Amikacinug/mL Amikacintranslation

1.637

Cap5-10ug/mL Capreomycintranslation

1.460

Rox10-50 ug/mL Roxithromycintranslation

1.610

SM2-5 ug/mL Streptomycintranslation

1.479

Tet5-10 ug/mL Tetracyclinetranslation

-1.198

Rif0.2-5ug/mL Rifampicintranscription

-0.369

Rifp0.1-0.5ug/mL Rifapentinetranscription

1.351

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.095

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.732

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.523

Clofazimine10-13 ug/mL Clofaziminerespiration

0.210

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.965

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.461

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-1.031

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.131

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.444

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-1.264

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.304

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.281

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.192

KCN5-20 ug/mL Potassium cyaniderespiration

-0.961

NaN30.2-2 mM Sodium aziderespiration

1.131

Nigericin50 uM Nigericinrespiration

-1.305

TRC10-150 ug/mL Triclosanrespiration

-0.943

TRZ10-25 ug/mL Thioridazinerespiration

1.233

Valinomycin0.5-10 uM Valinomycinrespiration

0.422

ZnSO42 mM ZnSO4respiration

0.568

menadione6-10 ug/mL Menadionerespiration

0.155

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.737

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.009

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.459

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

1.099

NRP_1Non-replicating persistence stage 1dosRassociated

0.896

Amp0.2mg/mL AmpicillincellWall

0.399

Cephalexin20-100 ug/mL CephalexincellWall

1.122

Cerulenin0.32-5 ug/mL CerulenincellWall

0.153

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.545

EMB10-20 ug/mL EthambutolcellWall

0.843

Eta12-40 ug/mL EthionamidecellWall

1.187

INH0.2-0.4 ug/mL IsoniazidcellWall

0.159

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.014

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.347

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.802

BZA0.12 mg/mL BenzamidearomaticAmides

-0.544

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.326

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.009

H2O24 mM hydrogen peroxideDNAdamaging

-0.065

Levo10 ug/mL LevofloxacinDNAdamaging

1.188

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.173

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.311

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.000

UVUV-irradiationDNAdamaging

-0.889

ARP41-4 ug/mL Antitubercular compound ARP4?

0.467

Antimycin12.5-50 ug/mL Antimycin A?

-0.063

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.364

PA_110-50 ug/mL Antitubercular compound PA-1?

0.382

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.397

PA8240.2-2 ug/mL PA-824?

-0.991

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.038

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.069

Verapamil50 uM Verapamil?

-0.035

mercaptoethanol2 mM 2-Mercaptoethanol?

0.272

methoxatin10-20 ug/mL Methoxatin?