from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2411c/-

LFCtreatmentdescriptionclass of inhibitor

0.143

Amikacinug/mL Amikacintranslation

-0.590

Cap5-10ug/mL Capreomycintranslation

-1.059

Rox10-50 ug/mL Roxithromycintranslation

-0.037

SM2-5 ug/mL Streptomycintranslation

-0.465

Tet5-10 ug/mL Tetracyclinetranslation

-0.136

Rif0.2-5ug/mL Rifampicintranscription

0.628

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.505

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.645

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.762

CPZ10-50 ug/mL Chlorpromazinerespiration

0.400

Clofazimine10-13 ug/mL Clofaziminerespiration

0.548

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.987

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.130

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.043

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.592

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.543

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.586

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.229

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.590

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-2.455

KCN5-20 ug/mL Potassium cyaniderespiration

-0.356

NaN30.2-2 mM Sodium aziderespiration

-0.294

Nigericin50 uM Nigericinrespiration

-0.392

TRC10-150 ug/mL Triclosanrespiration

1.029

TRZ10-25 ug/mL Thioridazinerespiration

-1.991

Valinomycin0.5-10 uM Valinomycinrespiration

1.047

ZnSO42 mM ZnSO4respiration

-0.649

menadione6-10 ug/mL Menadionerespiration

-0.225

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-1.007

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.400

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.198

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.555

NRP_1Non-replicating persistence stage 1dosRassociated

0.520

Amp0.2mg/mL AmpicillincellWall

0.004

Cephalexin20-100 ug/mL CephalexincellWall

0.322

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.223

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.332

EMB10-20 ug/mL EthambutolcellWall

0.921

Eta12-40 ug/mL EthionamidecellWall

0.844

INH0.2-0.4 ug/mL IsoniazidcellWall

0.904

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.239

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.050

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.058

BZA0.12 mg/mL BenzamidearomaticAmides

-0.228

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.350

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.188

H2O24 mM hydrogen peroxideDNAdamaging

0.081

Levo10 ug/mL LevofloxacinDNAdamaging

-0.098

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.551

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.048

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.564

UVUV-irradiationDNAdamaging

0.347

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.195

Antimycin12.5-50 ug/mL Antimycin A?

0.050

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.222

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.562

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.659

PA8240.2-2 ug/mL PA-824?

-0.029

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.436

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.114

Verapamil50 uM Verapamil?

-0.645

mercaptoethanol2 mM 2-Mercaptoethanol?

0.233

methoxatin10-20 ug/mL Methoxatin?