from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2355/-

LFCtreatmentdescriptionclass of inhibitor

-0.121

Amikacinug/mL Amikacintranslation

0.496

Cap5-10ug/mL Capreomycintranslation

0.418

Rox10-50 ug/mL Roxithromycintranslation

0.002

SM2-5 ug/mL Streptomycintranslation

-0.175

Tet5-10 ug/mL Tetracyclinetranslation

-0.189

Rif0.2-5ug/mL Rifampicintranscription

-0.213

Rifp0.1-0.5ug/mL Rifapentinetranscription

1.005

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.818

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.306

CPZ10-50 ug/mL Chlorpromazinerespiration

0.107

Clofazimine10-13 ug/mL Clofaziminerespiration

0.816

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.821

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.084

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.830

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.574

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.110

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.388

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.175

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.926

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.498

KCN5-20 ug/mL Potassium cyaniderespiration

0.593

NaN30.2-2 mM Sodium aziderespiration

1.277

Nigericin50 uM Nigericinrespiration

0.021

TRC10-150 ug/mL Triclosanrespiration

-0.572

TRZ10-25 ug/mL Thioridazinerespiration

2.389

Valinomycin0.5-10 uM Valinomycinrespiration

0.842

ZnSO42 mM ZnSO4respiration

-1.231

menadione6-10 ug/mL Menadionerespiration

-0.591

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.204

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.443

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.917

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.515

NRP_1Non-replicating persistence stage 1dosRassociated

-0.211

Amp0.2mg/mL AmpicillincellWall

-0.274

Cephalexin20-100 ug/mL CephalexincellWall

0.093

Cerulenin0.32-5 ug/mL CerulenincellWall

0.262

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.086

EMB10-20 ug/mL EthambutolcellWall

0.104

Eta12-40 ug/mL EthionamidecellWall

-0.079

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.108

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.882

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.700

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.752

BZA0.12 mg/mL BenzamidearomaticAmides

-0.929

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.538

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.260

H2O24 mM hydrogen peroxideDNAdamaging

-0.026

Levo10 ug/mL LevofloxacinDNAdamaging

-0.437

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.179

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.229

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.472

UVUV-irradiationDNAdamaging

-0.893

ARP41-4 ug/mL Antitubercular compound ARP4?

0.274

Antimycin12.5-50 ug/mL Antimycin A?

0.342

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.466

PA_110-50 ug/mL Antitubercular compound PA-1?

0.801

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.216

PA8240.2-2 ug/mL PA-824?

-0.581

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.230

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.038

Verapamil50 uM Verapamil?

0.126

mercaptoethanol2 mM 2-Mercaptoethanol?

0.646

methoxatin10-20 ug/mL Methoxatin?