from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2338c/moeW

LFCtreatmentdescriptionclass of inhibitor

-1.492

Amikacinug/mL Amikacintranslation

0.224

Cap5-10ug/mL Capreomycintranslation

-0.983

Rox10-50 ug/mL Roxithromycintranslation

-0.066

SM2-5 ug/mL Streptomycintranslation

-0.776

Tet5-10 ug/mL Tetracyclinetranslation

-0.073

Rif0.2-5ug/mL Rifampicintranscription

0.213

Rifp0.1-0.5ug/mL Rifapentinetranscription

2.658

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

2.209

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.335

CPZ10-50 ug/mL Chlorpromazinerespiration

0.776

Clofazimine10-13 ug/mL Clofaziminerespiration

0.486

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.887

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

2.323

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.210

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.816

Econazole10-24 ug/mL Econazole (azole drug)respiration

1.181

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.511

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.312

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-1.090

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.801

KCN5-20 ug/mL Potassium cyaniderespiration

-0.018

NaN30.2-2 mM Sodium aziderespiration

0.634

Nigericin50 uM Nigericinrespiration

0.540

TRC10-150 ug/mL Triclosanrespiration

0.290

TRZ10-25 ug/mL Thioridazinerespiration

-1.568

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-1.290

menadione6-10 ug/mL Menadionerespiration

-0.076

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.024

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.104

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.784

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-2.947

NRP_1Non-replicating persistence stage 1dosRassociated

-0.241

Amp0.2mg/mL AmpicillincellWall

-0.691

Cephalexin20-100 ug/mL CephalexincellWall

-0.297

Cerulenin0.32-5 ug/mL CerulenincellWall

0.047

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.686

EMB10-20 ug/mL EthambutolcellWall

0.568

Eta12-40 ug/mL EthionamidecellWall

0.457

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.047

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.853

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.572

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.912

BZA0.12 mg/mL BenzamidearomaticAmides

-0.428

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.296

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.230

H2O24 mM hydrogen peroxideDNAdamaging

-0.379

Levo10 ug/mL LevofloxacinDNAdamaging

-0.163

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.114

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.129

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.476

UVUV-irradiationDNAdamaging

-0.496

ARP41-4 ug/mL Antitubercular compound ARP4?

0.354

Antimycin12.5-50 ug/mL Antimycin A?

0.418

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.044

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.084

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.448

PA8240.2-2 ug/mL PA-824?

0.263

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.384

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.517

Verapamil50 uM Verapamil?

-0.160

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.308

methoxatin10-20 ug/mL Methoxatin?