from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2333c/stp

LFCtreatmentdescriptionclass of inhibitor

-0.160

Amikacinug/mL Amikacintranslation

0.061

Cap5-10ug/mL Capreomycintranslation

0.504

Rox10-50 ug/mL Roxithromycintranslation

-0.511

SM2-5 ug/mL Streptomycintranslation

-0.133

Tet5-10 ug/mL Tetracyclinetranslation

0.234

Rif0.2-5ug/mL Rifampicintranscription

-0.042

Rifp0.1-0.5ug/mL Rifapentinetranscription

2.551

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.509

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.805

CPZ10-50 ug/mL Chlorpromazinerespiration

1.199

Clofazimine10-13 ug/mL Clofaziminerespiration

0.557

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.459

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.540

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.532

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.973

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.378

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.560

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.261

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.348

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.441

KCN5-20 ug/mL Potassium cyaniderespiration

-0.198

NaN30.2-2 mM Sodium aziderespiration

-0.110

Nigericin50 uM Nigericinrespiration

0.495

TRC10-150 ug/mL Triclosanrespiration

1.451

TRZ10-25 ug/mL Thioridazinerespiration

1.344

Valinomycin0.5-10 uM Valinomycinrespiration

3.988

ZnSO42 mM ZnSO4respiration

0.070

menadione6-10 ug/mL Menadionerespiration

0.484

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

1.394

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.139

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.441

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.488

NRP_1Non-replicating persistence stage 1dosRassociated

-0.827

Amp0.2mg/mL AmpicillincellWall

-0.067

Cephalexin20-100 ug/mL CephalexincellWall

0.092

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.422

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.549

EMB10-20 ug/mL EthambutolcellWall

-0.450

Eta12-40 ug/mL EthionamidecellWall

-0.766

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.227

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.490

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.031

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.314

BZA0.12 mg/mL BenzamidearomaticAmides

-0.817

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.716

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.083

H2O24 mM hydrogen peroxideDNAdamaging

0.262

Levo10 ug/mL LevofloxacinDNAdamaging

-0.952

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.075

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.043

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.666

UVUV-irradiationDNAdamaging

2.209

ARP41-4 ug/mL Antitubercular compound ARP4?

0.242

Antimycin12.5-50 ug/mL Antimycin A?

0.208

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.698

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.443

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.279

PA8240.2-2 ug/mL PA-824?

0.019

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.159

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.752

Verapamil50 uM Verapamil?

0.110

mercaptoethanol2 mM 2-Mercaptoethanol?

0.177

methoxatin10-20 ug/mL Methoxatin?