from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2296/-

LFCtreatmentdescriptionclass of inhibitor

0.597

Amikacinug/mL Amikacintranslation

-0.242

Cap5-10ug/mL Capreomycintranslation

-0.532

Rox10-50 ug/mL Roxithromycintranslation

0.047

SM2-5 ug/mL Streptomycintranslation

0.543

Tet5-10 ug/mL Tetracyclinetranslation

0.878

Rif0.2-5ug/mL Rifampicintranscription

1.572

Rifp0.1-0.5ug/mL Rifapentinetranscription

1.164

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

1.813

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.133

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.000

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.013

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

1.566

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.627

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

1.248

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.519

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.170

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.717

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.218

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.507

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.365

KCN5-20 ug/mL Potassium cyaniderespiration

0.277

NaN30.2-2 mM Sodium aziderespiration

-0.036

Nigericin50 uM Nigericinrespiration

0.450

TRC10-150 ug/mL Triclosanrespiration

1.054

TRZ10-25 ug/mL Thioridazinerespiration

-0.106

Valinomycin0.5-10 uM Valinomycinrespiration

-0.655

ZnSO42 mM ZnSO4respiration

0.712

menadione6-10 ug/mL Menadionerespiration

0.579

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.644

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.353

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.569

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.446

NRP_1Non-replicating persistence stage 1dosRassociated

-0.037

Amp0.2mg/mL AmpicillincellWall

-0.059

Cephalexin20-100 ug/mL CephalexincellWall

-0.388

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.839

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.090

EMB10-20 ug/mL EthambutolcellWall

0.274

Eta12-40 ug/mL EthionamidecellWall

-0.064

INH0.2-0.4 ug/mL IsoniazidcellWall

0.078

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.401

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.726

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.317

BZA0.12 mg/mL BenzamidearomaticAmides

-0.354

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.312

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.149

H2O24 mM hydrogen peroxideDNAdamaging

-0.198

Levo10 ug/mL LevofloxacinDNAdamaging

-1.132

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.294

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.137

Oflox5-10 ug/mL OfloxacinDNAdamaging

-1.705

UVUV-irradiationDNAdamaging

1.872

ARP41-4 ug/mL Antitubercular compound ARP4?

0.089

Antimycin12.5-50 ug/mL Antimycin A?

0.209

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.502

PA_110-50 ug/mL Antitubercular compound PA-1?

0.238

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.262

PA8240.2-2 ug/mL PA-824?

0.859

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

1.181

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.019

Verapamil50 uM Verapamil?

0.548

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.999

methoxatin10-20 ug/mL Methoxatin?