from: <A HREF='https://pubmed.ncbi.nlm.nih.gov/15247240/'>Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.</A>

<H3>Gene Expression Profile for Rv2246/kasB</H3>
<table border=1>
<TD>LFC<TD>treatment<TD>description<TD>class of inhibitor<TR>
<TD><p style="background-color:rgb(255,122,122);">-2.084</p><TD>Amikacin<TD>ug/mL Amikacin<TD>translation<TR>
<TD><p style="background-color:rgb(255,145,145);">-1.725</p><TD>Cap<TD>5-10ug/mL Capreomycin<TD>translation<TR>
<TD><p style="background-color:rgb(255,157,157);">-1.541</p><TD>Rox<TD>10-50 ug/mL Roxithromycin<TD>translation<TR>
<TD><p style="background-color:rgb(255,197,197);">-0.913</p><TD>SM<TD>2-5 ug/mL Streptomycin<TD>translation<TR>
<TD><p style="background-color:rgb(255,142,142);">-1.779</p><TD>Tet<TD>5-10 ug/mL Tetracycline<TD>translation<TR>
<TD><p style="background-color:rgb(255,187,187);">-1.070</p><TD>Rif<TD>0.2-5ug/mL Rifampicin<TD>transcription<TR>
<TD><p style="background-color:rgb(255,236,236);">-0.304</p><TD>Rifp<TD>0.1-0.5ug/mL Rifapentine<TD>transcription<TR>
<TD><p style="background-color:rgb(251,251,255);">0.072</p><TD>Min_med__succinate_<TD>Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerol<TD>starvation<TR>
<TD><p style="background-color:rgb(255,169,169);">-1.351</p><TD>CCCP<TD>10-50 uM Carbonyl cyanide 3-chlorophenylhydrazone<TD>respiration<TR>
<TD><p style="background-color:rgb(255,237,237);">-0.291</p><TD>CPZ<TD>10-50 ug/mL Chlorpromazine<TD>respiration<TR>
<TD><p style="background-color:rgb(219,219,255);">0.568</p><TD>Clofazimine<TD>10-13 ug/mL Clofazimine<TD>respiration<TR>
<TD><p style="background-color:rgb(229,229,255);">0.421</p><TD>Clotrimazole<TD>10-24 ug/mL Clotrimazole (azole drug)<TD>respiration<TR>
<TD><p style="background-color:rgb(255,205,205);">-0.795</p><TD>DCCD<TD>20-100 uM Dicyclohexylcarbodiimide<TD>respiration<TR>
<TD><p style="background-color:rgb(255,235,235);">-0.323</p><TD>DNP<TD>"0.5-2.5 mM 2,4-Dinitrophenol"<TD>respiration<TR>
<TD><p style="background-color:rgb(255,168,168);">-1.375</p><TD>DTT<TD>"1-2 mM 1,4-Dithio-DL-threitol"<TD>respiration<TR>
<TD><p style="background-color:rgb(243,243,255);">0.201</p><TD>Econazole<TD>10-24 ug/mL Econazole (azole drug)<TD>respiration<TR>
<TD><p style="background-color:rgb(205,205,255);">0.787</p><TD>GSNO_CFZ<TD>0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofazimine<TD>respiration<TR>
<TD><p style="background-color:rgb(255,203,203);">-0.815</p><TD>GSNO_CPZ<TD>0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazine<TD>respiration<TR>
<TD><p style="background-color:rgb(255,244,244);">-0.184</p><TD>GSNO_KCN<TD>0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyanide<TD>respiration<TR>
<TD><p style="background-color:rgb(255,193,193);">-0.982</p><TD>GSNO_menadione<TD>0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadione<TD>respiration<TR>
<TD><p style="background-color:rgb(255,235,235);">-0.314</p><TD>KCN<TD>5-20 ug/mL Potassium cyanide<TD>respiration<TR>
<TD><p style="background-color:rgb(255,252,252);">-0.057</p><TD>NaN3<TD>0.2-2 mM Sodium azide<TD>respiration<TR>
<TD><p style="background-color:rgb(255,236,236);">-0.306</p><TD>Nigericin<TD>50 uM Nigericin<TD>respiration<TR>
<TD><p style="background-color:rgb(255,178,178);">-1.214</p><TD>TRC<TD>10-150 ug/mL Triclosan<TD>respiration<TR>
<TD><p style="background-color:rgb(255,236,236);">-0.301</p><TD>TRZ<TD>10-25 ug/mL Thioridazine<TD>respiration<TR>
<TD><p style="background-color:rgb(255,204,204);">-0.805</p><TD>Valinomycin<TD>0.5-10 uM Valinomycin<TD>respiration<TR>
<TD><p style="background-color:rgb(246,246,255);">0.153</p><TD>ZnSO4<TD>2 mM ZnSO4<TD>respiration<TR>
<TD><p style="background-color:rgb(255,192,192);">-0.997</p><TD>menadione<TD>6-10 ug/mL Menadione<TD>respiration<TR>
<TD><p style="background-color:rgb(255,241,241);">-0.220</p><TD>Ascididemin_Nat_prod<TD>4-9 ug/mL Organic extract of Eudistoma amplum<TD>ironLimitation<TR>
<TD><p style="background-color:rgb(224,224,255);">0.499</p><TD>Deferoxamine<TD>150-250 uM Deferoxamine mesylate<TD>ironLimitation<TR>
<TD><p style="background-color:rgb(227,227,255);">0.450</p><TD>Dipyridyl<TD>"100-200 uM 2,2'-Bipyridyl"<TD>ironLimitation<TR>
<TD><p style="background-color:rgb(217,217,255);">0.602</p><TD>GSNO<TD>0.02-0.1mM S-Nitrosoglutathione<TD>dosRassociated<TR>
<TD><p style="background-color:rgb(241,241,255);">0.225</p><TD>NRP_1<TD>Non-replicating persistence stage 1<TD>dosRassociated<TR>
<TD><p style="background-color:rgb(214,214,255);">0.652</p><TD>Amp<TD>0.2mg/mL Ampicillin<TD>cellWall<TR>
<TD><p style="background-color:rgb(232,232,255);">0.364</p><TD>Cephalexin<TD>20-100 ug/mL Cephalexin<TD>cellWall<TR>
<TD><p style="background-color:rgb(193,193,255);">0.983</p><TD>Cerulenin<TD>0.32-5 ug/mL Cerulenin<TD>cellWall<TR>
<TD><p style="background-color:rgb(248,248,255);">0.117</p><TD>DIPED<TD>5-100 ug/mL Diisopropylethylenediamine<TD>cellWall<TR>
<TD><p style="background-color:rgb(224,224,255);">0.496</p><TD>EMB<TD>10-20 ug/mL Ethambutol<TD>cellWall<TR>
<TD><p style="background-color:rgb(70,70,255);">2.894</p><TD>Eta<TD>12-40 ug/mL Ethionamide<TD>cellWall<TR>
<TD><p style="background-color:rgb(55,55,255);">3.128</p><TD>INH<TD>0.2-0.4 ug/mL Isoniazid<TD>cellWall<TR>
<TD><p style="background-color:rgb(81,81,255);">2.729</p><TD>TLM<TD>0.1-0.2 mg/mL Thiolactomycin<TD>cellWall<TR>
<TD><p style="background-color:rgb(229,229,255);">0.412</p><TD>Palmitate<TD>Minimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole Csource<TD>carbonSource<TR>
<TD><p style="background-color:rgb(225,225,255);">0.476</p><TD>Succinate<TD>Minimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole Csource<TD>carbonSource<TR>
<TD><p style="background-color:rgb(255,230,230);">-0.398</p><TD>BZA<TD>0.12 mg/mL Benzamide<TD>aromaticAmides<TR>
<TD><p style="background-color:rgb(243,243,255);">0.189</p><TD>Nam<TD>0.12 - 1.2 mg/mL Nicotinamide<TD>aromaticAmides<TR>
<TD><p style="background-color:rgb(227,227,255);">0.445</p><TD>PZA<TD>0.12-1.2 mg/mL Pyrazinamide<TD>aromaticAmides<TR>
<TD><p style="background-color:rgb(232,232,255);">0.362</p><TD>H2O2<TD>4 mM hydrogen peroxide<TD>DNAdamaging<TR>
<TD><p style="background-color:rgb(238,238,255);">0.272</p><TD>Levo<TD>10 ug/mL Levofloxacin<TD>DNAdamaging<TR>
<TD><p style="background-color:rgb(205,205,255);">0.793</p><TD>Mtm<TD>0.1-0.2 ug/mL Mitomycin C<TD>DNAdamaging<TR>
<TD><p style="background-color:rgb(215,215,255);">0.633</p><TD>Novobiocin<TD>10 ug/mL Novobiocin<TD>DNAdamaging<TR>
<TD><p style="background-color:rgb(255,226,226);">-0.465</p><TD>Oflox<TD>5-10 ug/mL Ofloxacin<TD>DNAdamaging<TR>
<TD><p style="background-color:rgb(218,218,255);">0.579</p><TD>UV<TD>UV-irradiation<TD>DNAdamaging<TR>
<TD><p style="background-color:rgb(251,251,255);">0.071</p><TD>ARP4<TD>1-4 ug/mL Antitubercular compound ARP4<TD>?<TR>
<TD><p style="background-color:rgb(255,242,242);">-0.214</p><TD>Antimycin<TD>12.5-50 ug/mL Antimycin A<TD>?<TR>
<TD><p style="background-color:rgb(227,227,255);">0.443</p><TD>DTNB<TD>"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"<TD>?<TR>
<TD><p style="background-color:rgb(228,228,255);">0.435</p><TD>PA_1<TD>10-50 ug/mL Antitubercular compound PA-1<TD>?<TR>
<TD><p style="background-color:rgb(236,236,255);">0.299</p><TD>PA_21<TD>10-50 ug/mL Antitubercular compound PA-21<TD>?<TR>
<TD><p style="background-color:rgb(235,235,255);">0.317</p><TD>PA824<TD>0.2-2 ug/mL PA-824<TD>?<TR>
<TD><p style="background-color:rgb(255,234,234);">-0.333</p><TD>Procept_6776<TD>20-30 ug/mL Antitubercular compound Procept 6776<TD>?<TR>
<TD><p style="background-color:rgb(251,251,255);">0.064</p><TD>Procept_6778<TD>5-40 ug/mL Antitubercular compound Procept 6778<TD>?<TR>
<TD><p style="background-color:rgb(237,237,255);">0.291</p><TD>Verapamil<TD>50 uM Verapamil<TD>?<TR>
<TD><p style="background-color:rgb(226,226,255);">0.454</p><TD>mercaptoethanol<TD>2 mM 2-Mercaptoethanol<TD>?<TR>
<TD><p style="background-color:rgb(245,245,255);">0.167</p><TD>methoxatin<TD>10-20 ug/mL Methoxatin<TD>?<TR>
</table>