from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2173/idsA2

LFCtreatmentdescriptionclass of inhibitor

0.333

Amikacinug/mL Amikacintranslation

-0.518

Cap5-10ug/mL Capreomycintranslation

-0.517

Rox10-50 ug/mL Roxithromycintranslation

-0.175

SM2-5 ug/mL Streptomycintranslation

-0.577

Tet5-10 ug/mL Tetracyclinetranslation

0.510

Rif0.2-5ug/mL Rifampicintranscription

0.214

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.359

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.818

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.419

CPZ10-50 ug/mL Chlorpromazinerespiration

1.027

Clofazimine10-13 ug/mL Clofaziminerespiration

0.070

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.696

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.408

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.451

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.499

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.086

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.012

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.694

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.243

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.474

KCN5-20 ug/mL Potassium cyaniderespiration

-0.556

NaN30.2-2 mM Sodium aziderespiration

1.012

Nigericin50 uM Nigericinrespiration

1.530

TRC10-150 ug/mL Triclosanrespiration

-0.297

TRZ10-25 ug/mL Thioridazinerespiration

-1.956

Valinomycin0.5-10 uM Valinomycinrespiration

0.192

ZnSO42 mM ZnSO4respiration

-0.878

menadione6-10 ug/mL Menadionerespiration

0.826

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.289

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.089

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.186

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.017

NRP_1Non-replicating persistence stage 1dosRassociated

-0.020

Amp0.2mg/mL AmpicillincellWall

0.582

Cephalexin20-100 ug/mL CephalexincellWall

0.360

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.008

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.382

EMB10-20 ug/mL EthambutolcellWall

0.807

Eta12-40 ug/mL EthionamidecellWall

0.903

INH0.2-0.4 ug/mL IsoniazidcellWall

0.312

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.002

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.105

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.306

BZA0.12 mg/mL BenzamidearomaticAmides

-0.399

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.652

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.501

H2O24 mM hydrogen peroxideDNAdamaging

0.493

Levo10 ug/mL LevofloxacinDNAdamaging

-0.789

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.320

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.271

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.541

UVUV-irradiationDNAdamaging

0.139

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.100

Antimycin12.5-50 ug/mL Antimycin A?

0.091

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.147

PA_110-50 ug/mL Antitubercular compound PA-1?

1.663

PA_2110-50 ug/mL Antitubercular compound PA-21?

1.363

PA8240.2-2 ug/mL PA-824?

0.174

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.382

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.631

Verapamil50 uM Verapamil?

-0.564

mercaptoethanol2 mM 2-Mercaptoethanol?

0.556

methoxatin10-20 ug/mL Methoxatin?