from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2154c/ftsW

LFCtreatmentdescriptionclass of inhibitor

-1.809

Amikacinug/mL Amikacintranslation

-1.008

Cap5-10ug/mL Capreomycintranslation

-2.551

Rox10-50 ug/mL Roxithromycintranslation

-0.432

SM2-5 ug/mL Streptomycintranslation

-1.828

Tet5-10 ug/mL Tetracyclinetranslation

-0.470

Rif0.2-5ug/mL Rifampicintranscription

-0.695

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.124

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

2.700

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.060

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.327

Clofazimine10-13 ug/mL Clofaziminerespiration

0.388

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.535

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.991

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.165

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.355

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.441

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.565

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

1.483

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.985

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

2.198

KCN5-20 ug/mL Potassium cyaniderespiration

0.301

NaN30.2-2 mM Sodium aziderespiration

-0.266

Nigericin50 uM Nigericinrespiration

0.609

TRC10-150 ug/mL Triclosanrespiration

-0.755

TRZ10-25 ug/mL Thioridazinerespiration

-0.650

Valinomycin0.5-10 uM Valinomycinrespiration

0.549

ZnSO42 mM ZnSO4respiration

-0.892

menadione6-10 ug/mL Menadionerespiration

-1.298

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.154

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.242

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.058

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-1.602

NRP_1Non-replicating persistence stage 1dosRassociated

0.328

Amp0.2mg/mL AmpicillincellWall

0.900

Cephalexin20-100 ug/mL CephalexincellWall

-0.477

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.273

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.287

EMB10-20 ug/mL EthambutolcellWall

0.398

Eta12-40 ug/mL EthionamidecellWall

0.122

INH0.2-0.4 ug/mL IsoniazidcellWall

0.369

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.760

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.946

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.466

BZA0.12 mg/mL BenzamidearomaticAmides

0.517

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.064

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.127

H2O24 mM hydrogen peroxideDNAdamaging

-0.701

Levo10 ug/mL LevofloxacinDNAdamaging

-0.267

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

1.702

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.799

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.192

UVUV-irradiationDNAdamaging

-1.018

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.721

Antimycin12.5-50 ug/mL Antimycin A?

0.248

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.323

PA_110-50 ug/mL Antitubercular compound PA-1?

0.030

PA_2110-50 ug/mL Antitubercular compound PA-21?

1.847

PA8240.2-2 ug/mL PA-824?

1.019

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.327

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.321

Verapamil50 uM Verapamil?

0.037

mercaptoethanol2 mM 2-Mercaptoethanol?

0.154

methoxatin10-20 ug/mL Methoxatin?