from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2120c/-

LFCtreatmentdescriptionclass of inhibitor

0.533

Amikacinug/mL Amikacintranslation

1.246

Cap5-10ug/mL Capreomycintranslation

3.581

Rox10-50 ug/mL Roxithromycintranslation

0.059

SM2-5 ug/mL Streptomycintranslation

0.602

Tet5-10 ug/mL Tetracyclinetranslation

0.580

Rif0.2-5ug/mL Rifampicintranscription

-0.011

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.423

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-2.155

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.892

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.207

Clofazimine10-13 ug/mL Clofaziminerespiration

0.435

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-2.080

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-2.238

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-1.191

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.026

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.326

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-1.164

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.978

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-1.107

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.768

KCN5-20 ug/mL Potassium cyaniderespiration

-0.303

NaN30.2-2 mM Sodium aziderespiration

0.297

Nigericin50 uM Nigericinrespiration

-0.216

TRC10-150 ug/mL Triclosanrespiration

-1.825

TRZ10-25 ug/mL Thioridazinerespiration

0.083

Valinomycin0.5-10 uM Valinomycinrespiration

0.447

ZnSO42 mM ZnSO4respiration

-0.840

menadione6-10 ug/mL Menadionerespiration

0.128

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.454

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.039

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.126

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.529

NRP_1Non-replicating persistence stage 1dosRassociated

0.411

Amp0.2mg/mL AmpicillincellWall

0.199

Cephalexin20-100 ug/mL CephalexincellWall

0.515

Cerulenin0.32-5 ug/mL CerulenincellWall

0.266

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.356

EMB10-20 ug/mL EthambutolcellWall

0.165

Eta12-40 ug/mL EthionamidecellWall

0.362

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.256

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.586

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.841

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.368

BZA0.12 mg/mL BenzamidearomaticAmides

0.234

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.247

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.402

H2O24 mM hydrogen peroxideDNAdamaging

0.229

Levo10 ug/mL LevofloxacinDNAdamaging

0.640

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.222

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.171

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.484

UVUV-irradiationDNAdamaging

-1.790

ARP41-4 ug/mL Antitubercular compound ARP4?

0.147

Antimycin12.5-50 ug/mL Antimycin A?

0.161

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.037

PA_110-50 ug/mL Antitubercular compound PA-1?

0.130

PA_2110-50 ug/mL Antitubercular compound PA-21?

-2.308

PA8240.2-2 ug/mL PA-824?

-1.035

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.042

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.137

Verapamil50 uM Verapamil?

0.170

mercaptoethanol2 mM 2-Mercaptoethanol?

0.095

methoxatin10-20 ug/mL Methoxatin?