from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2055c/rpsR2

LFCtreatmentdescriptionclass of inhibitor

0.342

Amikacinug/mL Amikacintranslation

0.201

Cap5-10ug/mL Capreomycintranslation

0.072

Rox10-50 ug/mL Roxithromycintranslation

0.315

SM2-5 ug/mL Streptomycintranslation

0.342

Tet5-10 ug/mL Tetracyclinetranslation

0.346

Rif0.2-5ug/mL Rifampicintranscription

0.277

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.792

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.221

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.042

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.435

Clofazimine10-13 ug/mL Clofaziminerespiration

0.221

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.859

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.611

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.067

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.286

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.515

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.312

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.011

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.176

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.438

KCN5-20 ug/mL Potassium cyaniderespiration

-0.057

NaN30.2-2 mM Sodium aziderespiration

-0.537

Nigericin50 uM Nigericinrespiration

-0.273

TRC10-150 ug/mL Triclosanrespiration

-0.824

TRZ10-25 ug/mL Thioridazinerespiration

2.093

Valinomycin0.5-10 uM Valinomycinrespiration

0.171

ZnSO42 mM ZnSO4respiration

0.222

menadione6-10 ug/mL Menadionerespiration

-0.119

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.191

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.116

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

1.190

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

1.148

NRP_1Non-replicating persistence stage 1dosRassociated

0.037

Amp0.2mg/mL AmpicillincellWall

0.253

Cephalexin20-100 ug/mL CephalexincellWall

0.150

Cerulenin0.32-5 ug/mL CerulenincellWall

0.315

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.199

EMB10-20 ug/mL EthambutolcellWall

0.083

Eta12-40 ug/mL EthionamidecellWall

0.173

INH0.2-0.4 ug/mL IsoniazidcellWall

0.131

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.564

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.408

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.111

BZA0.12 mg/mL BenzamidearomaticAmides

0.005

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.003

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.159

H2O24 mM hydrogen peroxideDNAdamaging

0.249

Levo10 ug/mL LevofloxacinDNAdamaging

0.407

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.210

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.015

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.169

UVUV-irradiationDNAdamaging

-0.057

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.097

Antimycin12.5-50 ug/mL Antimycin A?

0.036

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.429

PA_110-50 ug/mL Antitubercular compound PA-1?

0.341

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.876

PA8240.2-2 ug/mL PA-824?

-3.109

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-2.500

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.245

Verapamil50 uM Verapamil?

-0.180

mercaptoethanol2 mM 2-Mercaptoethanol?

0.189

methoxatin10-20 ug/mL Methoxatin?