from: <A HREF='https://pubmed.ncbi.nlm.nih.gov/15247240/'>Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.</A>

<H3>Gene Expression Profile for Rv2043c/pncA</H3>
<table border=1>
<TD>LFC<TD>treatment<TD>description<TD>class of inhibitor<TR>
<TD><p style="background-color:rgb(239,239,255);">0.253</p><TD>Amikacin<TD>ug/mL Amikacin<TD>translation<TR>
<TD><p style="background-color:rgb(255,232,232);">-0.370</p><TD>Cap<TD>5-10ug/mL Capreomycin<TD>translation<TR>
<TD><p style="background-color:rgb(244,244,255);">0.180</p><TD>Rox<TD>10-50 ug/mL Roxithromycin<TD>translation<TR>
<TD><p style="background-color:rgb(255,255,255);">-0.007</p><TD>SM<TD>2-5 ug/mL Streptomycin<TD>translation<TR>
<TD><p style="background-color:rgb(199,199,255);">0.888</p><TD>Tet<TD>5-10 ug/mL Tetracycline<TD>translation<TR>
<TD><p style="background-color:rgb(255,202,202);">-0.843</p><TD>Rif<TD>0.2-5ug/mL Rifampicin<TD>transcription<TR>
<TD><p style="background-color:rgb(255,248,248);">-0.121</p><TD>Rifp<TD>0.1-0.5ug/mL Rifapentine<TD>transcription<TR>
<TD><p style="background-color:rgb(255,143,143);">-1.763</p><TD>Min_med__succinate_<TD>Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerol<TD>starvation<TR>
<TD><p style="background-color:rgb(210,210,255);">0.707</p><TD>CCCP<TD>10-50 uM Carbonyl cyanide 3-chlorophenylhydrazone<TD>respiration<TR>
<TD><p style="background-color:rgb(179,179,255);">1.190</p><TD>CPZ<TD>10-50 ug/mL Chlorpromazine<TD>respiration<TR>
<TD><p style="background-color:rgb(195,195,255);">0.943</p><TD>Clofazimine<TD>10-13 ug/mL Clofazimine<TD>respiration<TR>
<TD><p style="background-color:rgb(236,236,255);">0.299</p><TD>Clotrimazole<TD>10-24 ug/mL Clotrimazole (azole drug)<TD>respiration<TR>
<TD><p style="background-color:rgb(154,154,255);">1.594</p><TD>DCCD<TD>20-100 uM Dicyclohexylcarbodiimide<TD>respiration<TR>
<TD><p style="background-color:rgb(204,204,255);">0.810</p><TD>DNP<TD>"0.5-2.5 mM 2,4-Dinitrophenol"<TD>respiration<TR>
<TD><p style="background-color:rgb(227,227,255);">0.451</p><TD>DTT<TD>"1-2 mM 1,4-Dithio-DL-threitol"<TD>respiration<TR>
<TD><p style="background-color:rgb(253,253,255);">0.045</p><TD>Econazole<TD>10-24 ug/mL Econazole (azole drug)<TD>respiration<TR>
<TD><p style="background-color:rgb(237,237,255);">0.292</p><TD>GSNO_CFZ<TD>0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofazimine<TD>respiration<TR>
<TD><p style="background-color:rgb(197,197,255);">0.912</p><TD>GSNO_CPZ<TD>0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazine<TD>respiration<TR>
<TD><p style="background-color:rgb(187,187,255);">1.066</p><TD>GSNO_KCN<TD>0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyanide<TD>respiration<TR>
<TD><p style="background-color:rgb(255,203,203);">-0.813</p><TD>GSNO_menadione<TD>0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadione<TD>respiration<TR>
<TD><p style="background-color:rgb(122,122,255);">2.079</p><TD>KCN<TD>5-20 ug/mL Potassium cyanide<TD>respiration<TR>
<TD><p style="background-color:rgb(246,246,255);">0.156</p><TD>NaN3<TD>0.2-2 mM Sodium azide<TD>respiration<TR>
<TD><p style="background-color:rgb(255,205,205);">-0.794</p><TD>Nigericin<TD>50 uM Nigericin<TD>respiration<TR>
<TD><p style="background-color:rgb(209,209,255);">0.723</p><TD>TRC<TD>10-150 ug/mL Triclosan<TD>respiration<TR>
<TD><p style="background-color:rgb(145,145,255);">1.720</p><TD>TRZ<TD>10-25 ug/mL Thioridazine<TD>respiration<TR>
<TD><p style="background-color:rgb(209,209,255);">0.733</p><TD>Valinomycin<TD>0.5-10 uM Valinomycin<TD>respiration<TR>
<TD><p style="background-color:rgb(255,180,180);">-1.182</p><TD>ZnSO4<TD>2 mM ZnSO4<TD>respiration<TR>
<TD><p style="background-color:rgb(255,233,233);">-0.344</p><TD>menadione<TD>6-10 ug/mL Menadione<TD>respiration<TR>
<TD><p style="background-color:rgb(240,240,255);">0.239</p><TD>Ascididemin_Nat_prod<TD>4-9 ug/mL Organic extract of Eudistoma amplum<TD>ironLimitation<TR>
<TD><p style="background-color:rgb(255,209,209);">-0.727</p><TD>Deferoxamine<TD>150-250 uM Deferoxamine mesylate<TD>ironLimitation<TR>
<TD><p style="background-color:rgb(255,226,226);">-0.454</p><TD>Dipyridyl<TD>"100-200 uM 2,2'-Bipyridyl"<TD>ironLimitation<TR>
<TD><p style="background-color:rgb(255,208,208);">-0.743</p><TD>GSNO<TD>0.02-0.1mM S-Nitrosoglutathione<TD>dosRassociated<TR>
<TD><p style="background-color:rgb(219,219,255);">0.569</p><TD>NRP_1<TD>Non-replicating persistence stage 1<TD>dosRassociated<TR>
<TD><p style="background-color:rgb(255,241,241);">-0.227</p><TD>Amp<TD>0.2mg/mL Ampicillin<TD>cellWall<TR>
<TD><p style="background-color:rgb(255,235,235);">-0.314</p><TD>Cephalexin<TD>20-100 ug/mL Cephalexin<TD>cellWall<TR>
<TD><p style="background-color:rgb(255,197,197);">-0.918</p><TD>Cerulenin<TD>0.32-5 ug/mL Cerulenin<TD>cellWall<TR>
<TD><p style="background-color:rgb(255,220,220);">-0.551</p><TD>DIPED<TD>5-100 ug/mL Diisopropylethylenediamine<TD>cellWall<TR>
<TD><p style="background-color:rgb(255,233,233);">-0.354</p><TD>EMB<TD>10-20 ug/mL Ethambutol<TD>cellWall<TR>
<TD><p style="background-color:rgb(255,240,240);">-0.246</p><TD>Eta<TD>12-40 ug/mL Ethionamide<TD>cellWall<TR>
<TD><p style="background-color:rgb(237,237,255);">0.288</p><TD>INH<TD>0.2-0.4 ug/mL Isoniazid<TD>cellWall<TR>
<TD><p style="background-color:rgb(255,224,224);">-0.489</p><TD>TLM<TD>0.1-0.2 mg/mL Thiolactomycin<TD>cellWall<TR>
<TD><p style="background-color:rgb(255,217,217);">-0.600</p><TD>Palmitate<TD>Minimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole Csource<TD>carbonSource<TR>
<TD><p style="background-color:rgb(255,221,221);">-0.539</p><TD>Succinate<TD>Minimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole Csource<TD>carbonSource<TR>
<TD><p style="background-color:rgb(255,229,229);">-0.408</p><TD>BZA<TD>0.12 mg/mL Benzamide<TD>aromaticAmides<TR>
<TD><p style="background-color:rgb(255,216,216);">-0.618</p><TD>Nam<TD>0.12 - 1.2 mg/mL Nicotinamide<TD>aromaticAmides<TR>
<TD><p style="background-color:rgb(253,253,255);">0.040</p><TD>PZA<TD>0.12-1.2 mg/mL Pyrazinamide<TD>aromaticAmides<TR>
<TD><p style="background-color:rgb(255,255,255);">-0.013</p><TD>H2O2<TD>4 mM hydrogen peroxide<TD>DNAdamaging<TR>
<TD><p style="background-color:rgb(255,242,242);">-0.207</p><TD>Levo<TD>10 ug/mL Levofloxacin<TD>DNAdamaging<TR>
<TD><p style="background-color:rgb(255,207,207);">-0.756</p><TD>Mtm<TD>0.1-0.2 ug/mL Mitomycin C<TD>DNAdamaging<TR>
<TD><p style="background-color:rgb(255,237,237);">-0.289</p><TD>Novobiocin<TD>10 ug/mL Novobiocin<TD>DNAdamaging<TR>
<TD><p style="background-color:rgb(255,254,254);">-0.018</p><TD>Oflox<TD>5-10 ug/mL Ofloxacin<TD>DNAdamaging<TR>
<TD><p style="background-color:rgb(255,240,240);">-0.241</p><TD>UV<TD>UV-irradiation<TD>DNAdamaging<TR>
<TD><p style="background-color:rgb(237,237,255);">0.285</p><TD>ARP4<TD>1-4 ug/mL Antitubercular compound ARP4<TD>?<TR>
<TD><p style="background-color:rgb(255,241,241);">-0.231</p><TD>Antimycin<TD>12.5-50 ug/mL Antimycin A<TD>?<TR>
<TD><p style="background-color:rgb(255,144,144);">-1.738</p><TD>DTNB<TD>"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"<TD>?<TR>
<TD><p style="background-color:rgb(240,240,255);">0.242</p><TD>PA_1<TD>10-50 ug/mL Antitubercular compound PA-1<TD>?<TR>
<TD><p style="background-color:rgb(255,255,255);">0.003</p><TD>PA_21<TD>10-50 ug/mL Antitubercular compound PA-21<TD>?<TR>
<TD><p style="background-color:rgb(122,122,255);">2.084</p><TD>PA824<TD>0.2-2 ug/mL PA-824<TD>?<TR>
<TD><p style="background-color:rgb(161,161,255);">1.472</p><TD>Procept_6776<TD>20-30 ug/mL Antitubercular compound Procept 6776<TD>?<TR>
<TD><p style="background-color:rgb(229,229,255);">0.411</p><TD>Procept_6778<TD>5-40 ug/mL Antitubercular compound Procept 6778<TD>?<TR>
<TD><p style="background-color:rgb(255,173,173);">-1.295</p><TD>Verapamil<TD>50 uM Verapamil<TD>?<TR>
<TD><p style="background-color:rgb(255,185,185);">-1.109</p><TD>mercaptoethanol<TD>2 mM 2-Mercaptoethanol<TD>?<TR>
<TD><p style="background-color:rgb(255,179,179);">-1.197</p><TD>methoxatin<TD>10-20 ug/mL Methoxatin<TD>?<TR>
</table>