from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2037c/-

LFCtreatmentdescriptionclass of inhibitor

0.372

Amikacinug/mL Amikacintranslation

0.117

Cap5-10ug/mL Capreomycintranslation

-0.296

Rox10-50 ug/mL Roxithromycintranslation

0.286

SM2-5 ug/mL Streptomycintranslation

1.261

Tet5-10 ug/mL Tetracyclinetranslation

-0.106

Rif0.2-5ug/mL Rifampicintranscription

0.515

Rifp0.1-0.5ug/mL Rifapentinetranscription

-1.455

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

2.316

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.591

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.078

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.901

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.059

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.488

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.498

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.311

Econazole10-24 ug/mL Econazole (azole drug)respiration

-1.315

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.822

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.249

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-1.119

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.038

KCN5-20 ug/mL Potassium cyaniderespiration

-1.933

NaN30.2-2 mM Sodium aziderespiration

1.400

Nigericin50 uM Nigericinrespiration

1.213

TRC10-150 ug/mL Triclosanrespiration

0.891

TRZ10-25 ug/mL Thioridazinerespiration

-0.440

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.793

menadione6-10 ug/mL Menadionerespiration

0.131

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.225

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.138

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.176

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

1.305

NRP_1Non-replicating persistence stage 1dosRassociated

-0.615

Amp0.2mg/mL AmpicillincellWall

-0.276

Cephalexin20-100 ug/mL CephalexincellWall

0.838

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.773

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.859

EMB10-20 ug/mL EthambutolcellWall

-0.930

Eta12-40 ug/mL EthionamidecellWall

-1.296

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.219

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.045

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.174

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.040

BZA0.12 mg/mL BenzamidearomaticAmides

0.344

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.186

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.217

H2O24 mM hydrogen peroxideDNAdamaging

-0.249

Levo10 ug/mL LevofloxacinDNAdamaging

-0.411

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.468

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.287

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.217

UVUV-irradiationDNAdamaging

1.121

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.462

Antimycin12.5-50 ug/mL Antimycin A?

-0.444

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.008

PA_110-50 ug/mL Antitubercular compound PA-1?

0.209

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.111

PA8240.2-2 ug/mL PA-824?

-0.238

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.104

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.013

Verapamil50 uM Verapamil?

-0.482

mercaptoethanol2 mM 2-Mercaptoethanol?

0.303

methoxatin10-20 ug/mL Methoxatin?