from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2014/-

LFCtreatmentdescriptionclass of inhibitor

0.905

Amikacinug/mL Amikacintranslation

0.563

Cap5-10ug/mL Capreomycintranslation

0.708

Rox10-50 ug/mL Roxithromycintranslation

0.407

SM2-5 ug/mL Streptomycintranslation

0.313

Tet5-10 ug/mL Tetracyclinetranslation

-0.413

Rif0.2-5ug/mL Rifampicintranscription

0.138

Rifp0.1-0.5ug/mL Rifapentinetranscription

-1.453

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.863

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.206

CPZ10-50 ug/mL Chlorpromazinerespiration

0.190

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.959

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

1.061

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.666

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.702

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.276

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.415

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.515

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.143

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

1.116

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.595

KCN5-20 ug/mL Potassium cyaniderespiration

1.265

NaN30.2-2 mM Sodium aziderespiration

0.431

Nigericin50 uM Nigericinrespiration

0.331

TRC10-150 ug/mL Triclosanrespiration

1.483

TRZ10-25 ug/mL Thioridazinerespiration

3.284

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

0.683

menadione6-10 ug/mL Menadionerespiration

-0.294

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.304

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.201

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.527

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.270

NRP_1Non-replicating persistence stage 1dosRassociated

-0.281

Amp0.2mg/mL AmpicillincellWall

-0.058

Cephalexin20-100 ug/mL CephalexincellWall

-0.328

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.485

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.098

EMB10-20 ug/mL EthambutolcellWall

-0.355

Eta12-40 ug/mL EthionamidecellWall

-0.803

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.386

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.836

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.766

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.122

BZA0.12 mg/mL BenzamidearomaticAmides

-0.149

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

1.053

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.351

H2O24 mM hydrogen peroxideDNAdamaging

0.299

Levo10 ug/mL LevofloxacinDNAdamaging

-0.548

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.451

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.245

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.809

UVUV-irradiationDNAdamaging

0.372

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.119

Antimycin12.5-50 ug/mL Antimycin A?

-0.376

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.133

PA_110-50 ug/mL Antitubercular compound PA-1?

0.064

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.278

PA8240.2-2 ug/mL PA-824?

-0.485

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.948

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.448

Verapamil50 uM Verapamil?

1.293

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.915

methoxatin10-20 ug/mL Methoxatin?