from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2002/fabG3

LFCtreatmentdescriptionclass of inhibitor

0.286

Amikacinug/mL Amikacintranslation

-0.908

Cap5-10ug/mL Capreomycintranslation

-0.551

Rox10-50 ug/mL Roxithromycintranslation

0.219

SM2-5 ug/mL Streptomycintranslation

0.383

Tet5-10 ug/mL Tetracyclinetranslation

0.487

Rif0.2-5ug/mL Rifampicintranscription

-0.484

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.513

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.179

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.231

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.433

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.281

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.940

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.355

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.242

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.891

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.044

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.139

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.546

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.739

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-2.240

KCN5-20 ug/mL Potassium cyaniderespiration

-0.027

NaN30.2-2 mM Sodium aziderespiration

-0.909

Nigericin50 uM Nigericinrespiration

0.223

TRC10-150 ug/mL Triclosanrespiration

-0.902

TRZ10-25 ug/mL Thioridazinerespiration

-0.831

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

0.921

menadione6-10 ug/mL Menadionerespiration

-0.171

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.151

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.004

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.085

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.050

NRP_1Non-replicating persistence stage 1dosRassociated

0.453

Amp0.2mg/mL AmpicillincellWall

0.259

Cephalexin20-100 ug/mL CephalexincellWall

-0.403

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.963

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.000

EMB10-20 ug/mL EthambutolcellWall

1.016

Eta12-40 ug/mL EthionamidecellWall

1.470

INH0.2-0.4 ug/mL IsoniazidcellWall

0.606

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.711

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.857

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.763

BZA0.12 mg/mL BenzamidearomaticAmides

0.732

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.545

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.708

H2O24 mM hydrogen peroxideDNAdamaging

-0.659

Levo10 ug/mL LevofloxacinDNAdamaging

0.124

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.652

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.040

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.502

UVUV-irradiationDNAdamaging

-0.244

ARP41-4 ug/mL Antitubercular compound ARP4?

0.323

Antimycin12.5-50 ug/mL Antimycin A?

-0.069

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.234

PA_110-50 ug/mL Antitubercular compound PA-1?

0.067

PA_2110-50 ug/mL Antitubercular compound PA-21?

-2.203

PA8240.2-2 ug/mL PA-824?

0.144

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.763

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.309

Verapamil50 uM Verapamil?

0.420

mercaptoethanol2 mM 2-Mercaptoethanol?

-1.310

methoxatin10-20 ug/mL Methoxatin?