from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1984c/cfp21

LFCtreatmentdescriptionclass of inhibitor

0.958

Amikacinug/mL Amikacintranslation

1.992

Cap5-10ug/mL Capreomycintranslation

1.795

Rox10-50 ug/mL Roxithromycintranslation

0.913

SM2-5 ug/mL Streptomycintranslation

2.174

Tet5-10 ug/mL Tetracyclinetranslation

0.250

Rif0.2-5ug/mL Rifampicintranscription

0.650

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.069

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.257

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.905

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.277

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.088

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.629

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.447

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.110

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.345

Econazole10-24 ug/mL Econazole (azole drug)respiration

-1.190

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.090

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.580

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.511

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.926

KCN5-20 ug/mL Potassium cyaniderespiration

0.128

NaN30.2-2 mM Sodium aziderespiration

0.989

Nigericin50 uM Nigericinrespiration

-0.574

TRC10-150 ug/mL Triclosanrespiration

-0.981

TRZ10-25 ug/mL Thioridazinerespiration

-1.023

Valinomycin0.5-10 uM Valinomycinrespiration

0.793

ZnSO42 mM ZnSO4respiration

0.235

menadione6-10 ug/mL Menadionerespiration

-0.553

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.197

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.125

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.868

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

1.154

NRP_1Non-replicating persistence stage 1dosRassociated

0.413

Amp0.2mg/mL AmpicillincellWall

0.299

Cephalexin20-100 ug/mL CephalexincellWall

0.907

Cerulenin0.32-5 ug/mL CerulenincellWall

0.467

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.249

EMB10-20 ug/mL EthambutolcellWall

1.283

Eta12-40 ug/mL EthionamidecellWall

1.729

INH0.2-0.4 ug/mL IsoniazidcellWall

0.749

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.664

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.254

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.120

BZA0.12 mg/mL BenzamidearomaticAmides

-0.784

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.992

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.219

H2O24 mM hydrogen peroxideDNAdamaging

0.788

Levo10 ug/mL LevofloxacinDNAdamaging

0.513

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.096

Novobiocin10 ug/mL NovobiocinDNAdamaging

1.251

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.073

UVUV-irradiationDNAdamaging

-0.607

ARP41-4 ug/mL Antitubercular compound ARP4?

0.210

Antimycin12.5-50 ug/mL Antimycin A?

0.116

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.492

PA_110-50 ug/mL Antitubercular compound PA-1?

0.347

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.925

PA8240.2-2 ug/mL PA-824?

-0.563

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.237

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.452

Verapamil50 uM Verapamil?

0.293

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.296

methoxatin10-20 ug/mL Methoxatin?